Unveiling the Potential of UBAC1: A Drug Target and Biomarker for Ubiquitin-Proteasome Complex (UPC) Disruptions
![Review Report on UBAC1 Target / Biomarker](https://silexon.ai/img/target-biomarker-review.jpg?a=1)
![Content of Review Report on UBAC1 Target / Biomarker](https://silexon.ai/img/target-biomarker-review-content.jpg?a=2)
Unveiling the Potential of UBAC1: A Drug Target and Biomarker for Ubiquitin-Proteasome Complex (UPC) Disruptions
Introduction
The ubiquitin-proteasome (UPC) complex is a crucial molecular machine that regulates protein degradation in cells. Disruptions in the UPC can lead to a range of cellular defects, including misfolded proteins, protein-protein interactions gone awry, and increased protein stability. UBAC1 protein, also known as Kip1 ubiquitination-promoting complex protein 2, is a key player in the regulation of UPC function. In this article, we will explore the potential of UBAC1 as a drug target and biomarker for UPC disruptions.
The UPC: A Complex Machine of Protein Degradation
The UPC is a highly conserved protein complex that plays a central role in regulating protein degradation in eukaryotic cells. It consists of a core protein, Kip1, and several peripheral proteins that form a framework for the recruitment of ubiquitin and other proteins for protein degradation. The UPC uses a hierarchical mechanism to recruit ubiquitin-proteasome (UPN) components to specific target proteins for degradation. UPNs are composed of a core protein and several peripheral proteins that form a ring-like structure around the UPN core. The UPN core can interact with the target protein to recruit it for degradation via the ubiquitin-proteasome interaction. Once recruited, the target protein is ubiquitinated and then processed by the UPN to remove the ubiquitin and release the protein for degradation.
UBAC1: A Key Player in the UPC
UBAC1, also known as Kip1 ubiquitination-promoting complex protein 2, is a 21-kDa protein that is highly conserved in both human and mouse cells. It is a key component of the UPC and plays a critical role in regulating the degradation of target proteins . UBAC1 is composed of a N-terminal region, a transmembrane region, and a C-terminal region. The N-terminal region contains a nucleotide-binding oligomerization domain (NBO), which is responsible for the interaction with UPNs. The transmembrane region contains a putative transmembrane domain and a carboxy-terminal region that is involved in the formation of the UPC. The C-terminal region contains a calcineurin-like domain, which is involved in the regulation of protein stability.
UBAC1's Role in UPC Function
UBAC1 is involved in multiple aspects of UPC function. First, it is the protein that forms the nucleotide-binding oligomerization domain (NBO) and interacts with UPNs to recruit them to the UPC. The NBO domain is responsible for the interaction with UPNs and is critical for the formation of the UPN. Second, UBAC1 is involved in the regulation of UPC stability. The calcineurin-like domain is involved in the regulation of protein stability and has been shown to play a role in the regulation of UPC stability. Finally, UBAC1 is involved in the degradation of target proteins. Once recruited to the UPC, UBAC1 is involved in the ubiquitination and degradation of target proteins.
The Potential of UBAC1 as a Drug Target
The discovery of UBAC1 as a potential drug target is an exciting development in the field of ubiquitin-proteasome (UPC) research. UBAC1 is a key player in the regulation of UPC function, and targeting it may be a promising strategy for the development of new UPC disruptions therapies. Several approaches have been proposed to target UBAC1, including small molecule inhibitors, monoclonal antibodies, and protein-based assays.
small molecule inhibitors:
Small molecule inhibitors have been shown to be effective in
Protein Name: UBA Domain Containing 1
Functions: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle
The "UBAC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBAC1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
UBAC2 | UBAC2-AS1 | UBALD1 | UBALD2 | UBAP1 | UBAP1L | UBAP2 | UBAP2L | UBASH3A | UBASH3B | UBB | UBBP1 | UBBP2 | UBBP4 | UBC | UBD | UBDP1 | UBE2A | UBE2B | UBE2C | UBE2CP3 | UBE2CP4 | UBE2D1 | UBE2D2 | UBE2D3 | UBE2D3P1 | UBE2D4 | UBE2DNL | UBE2E1 | UBE2E2 | UBE2E3 | UBE2F | UBE2F-SCLY | UBE2FP1 | UBE2G1 | UBE2G2 | UBE2H | UBE2HP1 | UBE2I | UBE2J1 | UBE2J2 | UBE2K | UBE2L1 | UBE2L3 | UBE2L6 | UBE2M | UBE2MP1 | UBE2N | UBE2NL | UBE2O | UBE2Q1 | UBE2Q2 | UBE2Q2P1 | UBE2Q2P11 | UBE2Q2P13 | UBE2Q2P16 | UBE2Q2P2 | UBE2QL1 | UBE2R2 | UBE2R2-AS1 | UBE2S | UBE2T | UBE2U | UBE2V1 | UBE2V1P2 | UBE2V1P9 | UBE2V2 | UBE2V2P1 | UBE2W | UBE2Z | UBE3A | UBE3B | UBE3C | UBE3D | UBE4A | UBE4B | UBFD1 | UBIAD1 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 | Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) complex | UBL3 | UBL4A | UBL4B | UBL5 | UBL5P3 | UBL7 | UBL7-DT | UBLCP1 | UBN1 | UBN2 | UBOX5 | UBOX5-AS1 | UBP1 | UBQLN1 | UBQLN1-AS1 | UBQLN2 | UBQLN3 | UBQLN4 | UBQLNL | UBR1