IBA57: A Potential Drug Target and Biomarker for Iron-Sulfur Cluster Assembly

Target Name: IBA57

NCBI ID: G200205

IBA57

IBA57: A Potential Drug Target and Biomarker for Iron-Sulfur Cluster Assembly

Iron-sulfur cluster assembly factor (ISAF) is a protein that plays a crucial role in the regulation of gene expression and cell signaling. ISAF functions as a scaffold to recruit other proteins to the ISAF-core protein, which is composed of an iron-sulfur cluster and several other subunits. The ISAF-core protein is highly conserved across various species, and its presence in various cellular processes suggests a universal function. ISAF has also been implicated in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, targeting ISAF has become an attractive research topic in recent years.

IBA57 is a protein that was identified as a potential drug target and biomarker for ISAF. IBA57 is a 57-kDa protein that is highly conserved across various species, including humans. It is localized to the endoplasmic reticulum (ER) and is involved in the regulation of protein stability and localization. IBA57 has been shown to interact with various ISAFs, including ISAF-1, ISAF-2, and ISAF-3. This interaction between IBA57 and ISAFs suggests that IBA57 may play a critical role in the regulation of ISAF function.

In addition to its interaction with ISAFs, IBA57 has been shown to play a role in the regulation of protein stability and localization. IBA57 is involved in the formation of a protein-protein interaction (PPI) complex with the protein heat shock protein (HSP) protein. This interaction between IBA57 and HSP has been shown to enhance the stability of IBA57 and to influence the localization of HSP to the endoplasmic reticulum.

IBA57 has also been shown to play a role in the regulation of cellular processes, including cell signaling, cell division, and apoptosis. IBA57 has been shown to be involved in the regulation of theNotch signaling pathway, a critical pathway that regulates cellular processes including stem cell maintenance, proliferation, and differentiation. IBA57 has also been shown to be involved in the regulation of the TGF-β pathway, a critical pathway that regulates cell signaling and development.

In conclusion, IBA57 is a protein that has been shown to interact with various ISAFs and to play a role in the regulation of protein stability and localization. This suggests that IBA57 may be a drug target and biomarker for ISAF. Further research is needed to fully understand the role of IBA57 in ISAF function and to determine the mechanisms by which IBA57 interacts with ISAFs. Understanding the role of IBA57 in ISAF function may have important implications for the development of new therapeutic strategies for a variety of diseases.

Protein Name: Iron-sulfur Cluster Assembly Factor IBA57

Functions: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway

The "IBA57 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IBA57 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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