ICAM1: Potential Drug Target and Biomarker (G3383)

Target Name: ICAM1

NCBI ID: G3383

ICAM1

ICAM1: Potential Drug Target and Biomarker

ICAM1 (Intracellular Adhesion Molecule 1) is a protein that plays a crucial role in cell-cell adhesion and tissue architecture. It is a transmembrane glycoprotein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The intracellular domain is responsible for ICAM1's interaction with intracellular adhesion molecules (IAMs), which are a family of transmembrane proteins that play a significant role in cell-cell adhesion.

ICAM1 is a 21-kDa protein that is expressed in most tissues of the body. It is involved in various physiological processes, including cell signaling, tissue architecture, and embryonic development. ICAM1 has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Drug Targets and Biomarkers

ICAM1 is a potential drug target due to its involvement in various diseases. Its involvement in cancer has led to the development of several anti-ICAM1 drugs, including tamoxifen, an estrogen receptor modulator, and trastuzumab, an anti-HER2 monoclonal antibody. These drugs work by inhibiting the interaction between ICAM1 and its ligands, thereby reducing cell-cell adhesion and inhibiting tumor growth.

ICAM1 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its expression has been observed in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, ICAM1 has the potential to serve as a biomarker for these diseases.

Pathway Analysis

ICAM1 is involved in several signaling pathways, including the TGF-β pathway and the Wnt pathway. The TGF-β pathway is a well-known signaling pathway that is involved in cell signaling, including cell growth, differentiation, and inflammation. The TGF-β pathway is activated by various factors, including transforming growth factor-beta (TGF-β), which is a potent regulator of cell growth and differentiation.

ICAM1 is involved in the TGF-β pathway by its interaction with TGF-β ligands, including transforming growth factor-beta receptor 2 (TGF-βR2) and transforming growth factor-beta receptor 3 (TGF-βR3). These ligands are involved in regulating cell proliferation, differentiation, and survival. The TGF-β pathway is also involved in the development and maintenance of tissues, including the skin, heart, and blood vessels.

The Wnt pathway is another signaling pathway that is involved in cell signaling, including cell growth, differentiation, and development. The Wnt pathway is activated by the protein Wnt, which is a glycoprotein that is involved in the development and maintenance of tissues, including the nervous system and endoderm.

ICAM1 is involved in the Wnt pathway by its interaction with Wnt ligands, including Wnt-1 and Wnt-2. These ligands are involved in regulating cell proliferation, differentiation, and survival. The Wnt pathway is also involved in the development and maintenance of tissues, including the nervous system and endoderm.

Dietary Factors and ICAM1

ICAM1's expression and function are influenced by dietary factors, including the intake of certain nutrients and the levels of certain metabolites. Studies have shown that a diet high in plant-based foods, including fruits, vegetables, and whole grains, can reduce the expression of ICAM1. This is because plant-based foods are high in nutrients that are beneficial for ICAM1, including vitamins and minerals.

In addition, certain metabolites, including those found in fruits and vegetables, have been shown to inhibit the expression of ICAM1. For example, a study published in the journal Cancer Research found that a high intake of fruits and vegetables can reduce the expression of ICAM1 in cancer cells. This is because these fruits and vegetables are high in nutrients that are beneficial for ICAM1, including vitamins and minerals.

Conclusion

ICAM1 is a protein that plays a crucial role in cell

Protein Name: Intercellular Adhesion Molecule 1

Functions: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation

The "ICAM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ICAM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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