Inhibiting RPC3: A Potential Strategy for Therapeutic Applications

Target Name: POLR3C

NCBI ID: G10623

POLR3C

Inhibiting RPC3: A Potential Strategy for Therapeutic Applications

POLR3C (DNA-directed RNA polymerase III subunit RPC3) is a protein that plays a crucial role in gene expression and DNA replication. It is a key component of the RNA polymerase III (RNA-pol) complex, which is responsible for generating RNA from DNA templates in the cytosol of eukaryotic cells.

The RNA-pol complex consists of several subunits, including RPC3, RPL12, RPL10, and RPL9, which work together to generate high-quality RNA products. RPC3 is one of the key subunits of the RNA-pol complex and is responsible for the initiation of the DNA-directed RNA polymerase reaction.

RPC3 is a 23 kDa protein that consists of 116 amino acid residues. It has a distinct N-terminal region that contains a single nucleotide (AUG) and a C-terminal region that contains a GCAATTTG repeat unit. The C-terminal region of RPC3 contains a single RNA-binding domain (RBD), which is responsible for the protein's ability to interact with RNA.

The RNA-binding domain of RPC3 is a critical region that allows the protein to interact with RNA polymerase II (RNA-pol II), which is a subunit of the RNA-pol complex that is responsible for the initiation of the DNA-directed RNA polymerase reaction. The RBD of RPC3 is responsible for the formation of a stable complex with RNA-pol II, which allows the initiation of the DNA-directed RNA polymerase reaction.

RPC3 is highly conserved and has a similar structure to other members of the RNA-pol complex. It is found in various organisms, including bacteria, archaea, and eukaryotes. It is also a good candidate for drug targeting, as some studies have suggested that inhibiting RPC3 may have therapeutic potential for various diseases.

One potential mechanism by which RPC3 may be targeted with drugs is by inhibiting the activity of RPC3. This could be done by inhibiting the activity of the RBD, which is the primary structural unit responsible for the protein's ability to interact with RNA. There are several potential strategies for inhibiting the activity of RPC3, including the use of small molecules, such as inhibitors of the RNA-pol complex, or the use of antibodies that specifically target the RBD.

Another approach to inhibiting the activity of RPC3 is to target the protein directly. This can be done through various techniques, such as cell-based assays, in vitro assays, or biochemical assays. For example, researchers have used cell-based assays to show that inhibiting the activity of RPC3 can inhibit the growth of cancer cells. In vitro assays have also been used to show that inhibiting the activity of RPC3 can inhibit the replication of RNA in the cytosol of eukaryotic cells.

In addition to its potential therapeutic applications, RPC3 is also a potential biomarker for various diseases. The RNA-pol complex is involved in the generation of RNA from DNA templates, which is a critical process for the development and progression of many diseases. Therefore, changes in the expression levels of RPC3 may be an indication of underlying diseases.

In conclusion, RPC3 is a key component of the RNA-pol complex that is responsible for the initiation of the DNA-directed RNA polymerase reaction. It is a highly conserved protein that is found in various organisms, including bacteria, archaea, and eukaryotes. In addition to its potential therapeutic applications, RPC3 is also a potential biomarker for various diseases. The RNA-pol complex is involved in

Protein Name: RNA Polymerase III Subunit C

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628)

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