WHAMM Protein: Key Regulator of Cell Growth and Differentiation
WHAMM Protein: Key Regulator of Cell Growth and Differentiation
The WHAMM (WAS protein homology region 2 domain containing 1) protein is a protein that is expressed in various tissues and cells in the human body. It is a key regulator of cell growth and differentiation, and is involved in the development and maintenance of tissues such as the brain, heart, and liver.
The WHAMM protein is made up of 252 amino acids and has a calculated molecular weight of 31.1 kDa. It is located in the cytoplasm and is primarily expressed in the brain, heart, and liver. It is also expressed in other tissues, such as the placenta and the testes.
The WHAMM protein is involved in several important cellular processes, including cell growth, differentiation, and inflammation. It plays a key role in the development and maintenance of tissues, and is involved in the formation of blood vessels, neural circuits, and the immune system.
One of the most promising aspects of the WHAMM protein is its potential as a drug target. The WHAMM protein has been shown to interact with several different drugs, including those that are used to treat a variety of diseases, such as cancer, heart disease, and neurological disorders.
In addition to its potential as a drug target, the WHAMM protein is also a potential biomarker. Its expression has been shown to be associated with several different diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This makes it an attractive candidate for use as a diagnostic marker or target for therapeutic intervention.
The WHAMM protein is also of interest to researchers because of its unique structure and function. Its homology region 2 domain, which is responsible for its interaction with other proteins, is similar to that of the protein tyrosine kinase TKT. This suggests that it may have similar functions to TKT, which is a known drug target for cancer.
In conclusion, the WHAMM protein is a key regulator of cell growth and differentiation that is expressed in various tissues and cells in the human body. Its expression is associated with several different diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function make it an attractive candidate for both drug targeting and biomarker development. Further research is needed to fully understand the role of the WHAMM protein in human health and disease.
Protein Name: WASP Homolog Associated With Actin, Golgi Membranes And Microtubules
Functions: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration
The "WHAMM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WHAMM comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
WHAMMP1 | WHAMMP2 | WHAMMP3 | WHRN | WIF1 | WIPF1 | WIPF2 | WIPF3 | WIPI1 | WIPI2 | WIZ | WLS | WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73 | WRN | WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP | WTAPP1 | WTIP | WWC1 | WWC2 | WWC2-AS2 | WWC3 | WWOX | WWP1 | WWP2 | WWTR1 | WWTR1-AS1 | XAB2 | XACT | XAF1 | XAGE-4 | XAGE1A | XAGE1B | XAGE1D | XAGE2 | XAGE3 | XAGE5 | XBP1 | XCL1 | XCL2 | XCR1 | XDH | XG | XGY2 | XIAP | XIRP1 | XIRP2 | XIST | XK | XKR3 | XKR4 | XKR5 | XKR6 | XKR7 | XKR8 | XKR9 | XKRX | XKRY | XKRYP7 | XLOC_007697 | XLOC_008559 | XLOC_009911 | XNDC1N | XPA | XPC | XPC complex | XPNPEP1 | XPNPEP2
