SPTLC1:Regulating Cell Adhesion and Signaling Pathways (G10558)

Target Name: SPTLC1

NCBI ID: G10558

SPTLC1

SPTLC1:Regulating Cell Adhesion and Signaling Pathways

SPTLC1 (SPTI) is a protein that is expressed in various tissues and cells in the human body. It is a member of the superfamily of cytoplasmic proteins (SCP), which are a group of proteins that are involved in various cellular processes. One of the key functions of SPTLC1 is its role in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs.

SPTLC1 is a 21-kDa protein that is expressed in a variety of tissues, including the brain, heart, and gastrointestinal tract. It is primarily localized to the cytoplasm of cells, where it is involved in the formation of tight junctions, which are specialized barriers that prevent substances from entering or leaving cells. tight junctions are important for maintaining the integrity of the blood-brain barrier, which is responsible for protecting the brain from harmful substances.

SPTLC1 has also been shown to play a role in the regulation of cell signaling pathways. Many signaling pathways in cells involve the formation of protein-protein interaction networks, which are critical for the regulation of cellular processes such as cell growth, differentiation, and inflammation. SPTLC1 is involved in the formation of these networks by interacting with various signaling proteins.

In addition to its role in cell signaling, SPTLC1 is also known for its role in the regulation of cell adhesion. SPTLC1 has been shown to interact with several adhesion molecules, including cadherin and immunoglobulin (Ig) G. These interactions are important for the formation of tight junctions, which are specialized barriers that prevent substances from entering or leaving cells. tight junctions are important for maintaining the integrity of the blood-brain barrier, which is responsible for protecting the brain from harmful substances.

SPTLC1 is also involved in the regulation of cell signaling pathways in cancer. Many studies have shown that SPTLC1 is involved in the regulation of various signaling pathways that are critical for the growth and survival of cancer cells. For example, SPTLC1 has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cellular processes such as cell growth, differentiation, and survival.

In conclusion, SPTLC1 is a protein that is involved in a variety of cellular processes in the human body. Its role in cell adhesion and signaling pathways is crucial for the regulation of cellular processes that are critical for the health and survival of cells. Further research is needed to fully understand the role of SPTLC1 in these processes and to develop new therapeutic approaches for the treatment of various diseases.

Protein Name: Serine Palmitoyltransferase Long Chain Base Subunit 1

Functions: Serine palmitoyltransferase (SPT) (PubMed:19416851). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851). The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851). Required for adipocyte cell viability and metabolic homeostasis (By similarity)

The "SPTLC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SPTLC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets