ENTHD1: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

Target Name: ENTHD1

NCBI ID: G150350

ENTHD1

ENTHD1: A Potential Drug Target and Biomarker for Neurodegenerative Diseases

ENTHD1 (ENTD1_HUMAN), a protein that is expressed in various tissues of the human body, has been identified as a potential drug target or biomarker in the field of neurodegenerative diseases. ENTHD1 has been shown to play a role in the development and progression of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

The ENTHD1 protein is a member of the Enthrichin family, which is characterized by the presence of a highly conserved N-terminal domain and a hydrophobic tryptophan side chain. ENTHD1 has multiple functions in cells, including participating in signal transduction, metabolism, cell adhesion, and intracellular transport. In addition, ENTHDF1 also has the ability to degrade modifications within cells, such as phosphorylation modifications and protein-protein interactions.

In neurodegenerative diseases, abnormal expression and dysfunction of ENTHD1 are considered to be one of the important reasons for the occurrence and development of many diseases. For example, studies have shown that overexpression of ENTHD1 is closely related to the occurrence and development of many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, the expression levels of genes related to ENTHD1 and some neurodegenerative diseases also show age dependence. For example, the expression level of ENTHD1 increases with age, which may reflect the age-related correlation of this protein in neurodegenerative diseases.

ENTHD1 is considered a potential drug target due to its abnormal expression and function in neurodegenerative diseases. Researchers have designed a variety of drugs targeting ENTHD1 and conducted preliminary in vitro and in vivo experiments. These drugs include small molecule compounds, large molecule drugs and biological agents.

In addition, ENTHD1 has also been used as a biomarker for neurological diseases. For example, studies have shown that ENTHD1 expression levels can serve as a potential biomarker for Parkinson's disease. In addition, the expression level of ENTHD1 can also serve as a biomarker for Alzheimer's disease and is related to the degree of neuronal loss and neuronal connectivity abnormalities.

ENTHD1 is a protein with important functions in neurological diseases. Through in-depth study of its expression and function, new ideas can be provided for the development of drugs to treat neurological diseases. Future research will continue to further investigate the role of ENTHD1 in neurodegenerative diseases and explore its clinical application prospects.

Protein Name: ENTH Domain Containing 1

The "ENTHD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ENTHD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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