Discovery, Structure, Function and Drug Targets of CYP4B1 (G1580)

Target Name: CYP4B1

NCBI ID: G1580

CYP4B1

Discovery, Structure, Function and Drug Targets of CYP4B1

CYP4B1, also known as microsomal monooxygenase, is an enzyme located in the mitochondria that plays a crucial role in the metabolism of various drugs. Its primary function is to metabolize drugs that have a long half-life, accumulate in the body, and have sustained effects on the human body Drug. Currently, CYP4B1 has become an important target in many drug research and development fields because it is considered to be the main metabolizing enzyme of many drugs in the body. This article will introduce in detail the discovery, structure, function and drug targets of CYP4B1.

1. Discovery of CYP4B1

The discovery of CYP4B1 originated from research on drug metabolism. As early as the 1950s, researchers began to study the metabolism of drugs in the body. At that time, researchers discovered that many drugs have long half-lives in the body and are difficult to remove from the body. This has led researchers to focus on drug-metabolizing enzymes, hoping to find an enzyme that can metabolize drugs quickly so that more effective drugs can be developed.

With the continuous development of science and technology, researchers have gradually gained a deeper understanding of drug metabolism. They found that the metabolism of many drugs occurs within the mitochondria within cells. This led researchers to study how drugs are metabolized within cells.

2. Structure of CYP4B1

CYP4B1 is a protein whose structure belongs to the endoplasmic reticulum subunit. It consists of 94 amino acids and its molecular weight is 36 kDa. The active center of CYP4B1 is a central 伪-helix, which contains a phenylalanine residue. Phenylalanine is a conserved group in the active center of CYP4B1. It can form a hydrophobic environment, allowing CYP4B1 to bind to the substrate and reduce the activity of the substrate.

The active center of CYP4B1 is a central 伪-helix, which contains a phenylalanine residue. Phenylalanine is a conserved group in the active center of CYP4B1. It can form a hydrophobic environment, allowing CYP4B1 to bind to the substrate and reduce the activity of the substrate.

3. Functions of CYP4B1

CYP4B1 is an important drug metabolizing enzyme that can catalyze the metabolism of many drugs. CYP4B1 is mainly involved in the following drug metabolism processes:

1. Analgesics: CYP4B1 is the main metabolic enzyme of many analgesics. It can catalyze the oxidation reaction of these drugs, thereby reducing their activity.

2. Sedative drugs: CYP4B1 is also the main metabolic enzyme of many sedative drugs. It can catalyze the oxidation reaction of these drugs, thereby reducing their activity.

3. Antibiotics: CYP4B1 can catalyze the metabolism of many antibiotics, including cephalosporins, ampicillin, etc.

4. Antidepressants: CYP4B1 can catalyze the metabolism of many antidepressants, including SSRI drugs.

5. Antihypertensive drugs: CYP4B1 can catalyze the metabolism of many antihypertensive drugs, including benazepril and eplerenone.

6. Hormones: CYP4B1 can catalyze the metabolism of many hormones, including testosterone, estrogen, etc.

CYP4B1 plays an important role in drug metabolism as it is able to catalyze the metabolism of many drugs, thereby reducing their activity. In addition, CYP4B1 can also regulate the concentration of drugs in the body, thereby affecting the efficacy and toxicity of drugs.

4. Drug targets of CYP4B1

CYP4B1 has become an important target in many drug development fields. Because CYP4B1 plays an important role in drug metabolism, it is widely used in drug development. Currently, CYP4B1 has become the target of many drugs, including the following aspects:

1. Antidepressants: CYP4B1 is the target of many antidepressants, including SSRI drugs. These drugs can increase their concentration in the body by inhibiting the activity of CYP4B1, thereby enhancing their efficacy.

2. Antidepressants: CYP4B1 is the target of many antidepressants, including SSRI drugs. These drugs can increase their concentration in the body by inhibiting the activity of CYP4B1, thereby enhancing their efficacy.

3. Antibiotics: CYP4

Protein Name: Cytochrome P450 Family 4 Subfamily B Member 1

Functions: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

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