Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype) Related Diseases

Amyloid beta A4 precursor protein-binding family (APP-BP) (nonspecified subtype)

Related Diseases

1) Creutzfeldt-Jakob Disease
Creutzfeldt-Jakob Disease, also known as variant creutzfeldt-jakob disease, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and prion disease, and has symptoms including back pain, headache and hemiparesis. An important gene associated with Creutzfeldt-Jakob Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Coal tar and Quinacrine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related phenotypes are dementia and neuronal loss in central nervous system

2) Huntington's Disease
Huntington Disease, also known as huntington's disease, is related to huntington disease-like 1 and choreatic disease, and has symptoms including back pain, headache and myoclonus. An important gene associated with Huntington Disease is HTT (Huntingtin), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Brain, eye and globus pallidus, and related phenotypes are chorea and mental deterioration

3) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

4) Stroke, Hemorrhagic
Hemorrhage, Intracerebral, also known as intracerebral hemorrhage, is related to cerebral amyloid angiopathy, app-related and porencephaly, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Hemorrhage, Intracerebral is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Progesterone and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are growth/size/body region and nervous system

5) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

6) Coronary Artery Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

7) Multiple Sclerosis, Relapsing-remitting
Relapsing-Remitting Multiple Sclerosis, also known as relapsing-remitting ms, is related to secondary progressive multiple sclerosis and multiple sclerosis. An important gene associated with Relapsing-Remitting Multiple Sclerosis is TUG1 (Taurine Up-Regulated 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Alemtuzumab and Phylloquinone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are growth/size/body region and homeostasis/metabolism

8) Multiple System Atrophy
Multiple System Atrophy 1, also known as multiple system atrophy, is related to pure autonomic failure and olivopontocerebellar atrophy. An important gene associated with Multiple System Atrophy 1 is COQ2 (Coenzyme Q2, Polyprenyltransferase), and among its related pathways/superpathways are Neuroscience and Neural Stem Cells and Lineage-specific Markers. The drugs Acetylcholine and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are abnormal pyramidal sign and dysarthria

9) Dementia
Dementia, also known as mental and behavioural disorders due to use of sedatives or hypnotics, residual and late-onset psychotic disorder, is related to dementia, lewy body and frontotemporal dementia, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Mirabegron and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and bone marrow, and related phenotypes are no effect and no effect

10) Wilson's Disease
Wilson Disease, also known as hepatolenticular degeneration, is related to disorder of copper metabolism and choreatic disease, and has symptoms including abdominal pain, back pain and constipation. An important gene associated with Wilson Disease is ATP7B (ATPase Copper Transporting Beta), and among its related pathways/superpathways are Ferroptosis and Detoxification of Reactive Oxygen Species. The drugs Zinc cation and Choline have been mentioned in the context of this disorder. Affiliated tissues include Liver, eye and brain, and related phenotypes are intellectual disability and failure to thrive

11) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

12) Myocardial Infarction
Myocardial Infarction, also known as heart attack, is related to lipoprotein quantitative trait locus and cardiovascular system disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Myocardial Infarction is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Bone and Limb.

13) Acute Myeloid Leukemia
Acute Myeloblastic Leukemia with Maturation, also known as acute myeloblastic leukemia type 2, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Acute Myeloblastic Leukemia with Maturation is MIR181A1HG (MIR181A1 Host Gene), and among its related pathways/superpathways are Ras signaling and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Nicotine and Amsacrine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

14) Sporadic Inclusion Body Myositis
Inclusion Body Myositis, also known as sporadic inclusion body myositis, is related to myositis and myopathy, and has symptoms including back pain, muscle cramp and muscle rigidity. An important gene associated with Inclusion Body Myositis is GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase), and among its related pathways/superpathways are Neuroscience and miRNAs involvement in the immune response in sepsis. The drugs Mycophenolic acid and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, bone and eye, and related phenotypes are skeletal muscle atrophy and autoimmunity

15) Amyloidosis
Amyloidosis, also known as amyloid disease, is related to amyloidosis, hereditary, transthyretin-related and immunoglobulin light chain amyloidosis. An important gene associated with Amyloidosis is TTR (Transthyretin), and among its related pathways/superpathways are Innate Immune System and Metabolism of proteins. The drugs Citalopram and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are no effect and no effect

16) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

17) Atopic Dermatitis
Dermatitis, Atopic, also known as atopic dermatitis, is related to allergic disease and dermatitis, atopic, 3, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis, Atopic is FLG (Filaggrin), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Cytokine Signaling in Immune system. The drugs Zinc oxide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are cataract and ichthyosis

18) Dementia, Vascular
Vascular Dementia, also known as dementia, vascular, is related to binswanger's disease and dementia. An important gene associated with Vascular Dementia is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Neuroscience. The drugs Acetaminophen and Hydrocodone have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart, and related phenotypes are nervous system and homeostasis/metabolism

19) Diabetic Neuropathy
Diabetic Neuropathy, also known as diabetic neuropathies, is related to microvascular complications of diabetes 3 and diabetic polyneuropathy, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and CREB Pathway. The drugs Histamine and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and dorsal root ganglion, and related phenotypes are no effect and no effect

20) Diabetic Nephropathy
Microvascular Complications of Diabetes 2, also known as microvascular complications of diabetes, susceptibility to, 2, is related to microvascular complications of diabetes 3 and background diabetic retinopathy. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and retina.

21) Fibrosis
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

22) Ischemia
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

23) Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1, also known as guam disease, is related to frontotemporal dementia and/or amyotrophic lateral sclerosis 3 and frontotemporal dementia and/or amyotrophic lateral sclerosis 2, and has symptoms including tremor, bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 is TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Varenicline and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spinal cord and brain, and related phenotypes are muscle weakness and dementia

24) Spinal Muscular Atrophy
Spinal Muscular Atrophy, also known as sma, is related to spinal muscular atrophy, distal, autosomal recessive, 1 and spinal muscular atrophy, x-linked 2, and has symptoms including back pain, headache and pain. An important gene associated with Spinal Muscular Atrophy is SMN1 (Survival Of Motor Neuron 1, Telomeric), and among its related pathways/superpathways is SARS-CoV-2 modulates host translation machinery. The drugs Acetaminophen and Risdiplam have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skeletal muscle and tongue, and related phenotypes are no effect and no effect

25) Cerebral Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Cst3-Related, also known as cerebral amyloid angiopathy, is related to cerebral amyloid angiopathy, app-related and gerstmann-straussler disease. An important gene associated with Cerebral Amyloid Angiopathy, Cst3-Related is CST3 (Cystatin C), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Presenilin-Mediated Signaling. The drugs Phenol and Acetylsalicylic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spleen, and related phenotypes are stroke and cerebral hemorrhage

26) Encephalopathy
Encephalopathy, also known as toxic cerebrospinal inflammation, is related to glycine encephalopathy and developmental and epileptic encephalopathy 1, and has symptoms including ataxia, athetosis and back pain. An important gene associated with Encephalopathy is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are Neuroscience and Dravet syndrome. The drugs Promethazine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and eye, and related phenotypes are no effect and no effect

27) Alopecia
Alopecia is related to alopecia universalis congenita and alopecia-mental retardation syndrome 1, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia is SASH1 (SAM And SH3 Domain Containing 1), and among its related pathways/superpathways are Direct p53 effectors and Validated transcriptional targets of TAp63 isoforms. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include Hair, and related phenotypes are no effect and no effect

28) Retinitis Pigmentosa
Cone-Rod Dystrophy 2, also known as cone-rod dystrophy, is related to cone-rod dystrophy 3 and cone-rod dystrophy 16. An important gene associated with Cone-Rod Dystrophy 2 is CRX (Cone-Rod Homeobox), and among its related pathways/superpathways are Bardet-Biedl syndrome and Ciliopathies. The drugs Tocopherol and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are abnormality of retinal pigmentation and photophobia

29) Lewy Body Dementia
Dementia, Lewy Body, also known as lewy body dementia, is related to parkinson disease 4, autosomal dominant and parkinson disease 1, autosomal dominant, and has symptoms including back pain, headache and pain. An important gene associated with Dementia, Lewy Body is SNCA (Synuclein Alpha), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Memantine and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and eye, and related phenotypes are dementia and visual hallucinations

30) Light Chain Amyloidosis
Immunoglobulin Light Chain Amyloidosis, also known as primary amyloidosis, is related to amyloid tumor and nephrotic syndrome. An important gene associated with Immunoglobulin Light Chain Amyloidosis is LYZ (Lysozyme), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Thalidomide and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and kidney, and related phenotypes are fatigue and proteinuria

31) Frontotemporal Dementia
Frontotemporal Dementia, also known as frontotemporal lobar degeneration, is related to inclusion body myopathy with paget disease of bone and frontotemporal dementia and frontotemporal dementia and/or amyotrophic lateral sclerosis 1, and has symptoms including myoclonus and personality changes. An important gene associated with Frontotemporal Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Neuroscience. The drugs Memantine and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and bone marrow, and related phenotypes are brain atrophy and visual agnosia

32) Osteopetrosis
Osteopetrosis, also known as marble bone disease, is related to osteopetrosis, autosomal recessive 7 and osteopetrosis, autosomal recessive 5. An important gene associated with Osteopetrosis is CLCN7 (Chloride Voltage-Gated Channel 7), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spleen, and related phenotypes are no effect and no effect

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