ABCC2: A Drug Target and Potential Biomarker for Chronic Kidney Disease

Target Name: ABCC2

NCBI ID: G1244

ABCC2

ABCC2: A Drug Target and Potential Biomarker for Chronic Kidney Disease

Abstract:

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality, affecting millions of people worldwide. The kidney function is heavily dependent on the function of the blood vessels, particularly the vasculature. The abnormalities in the vasculature, leading to decreased kidney blood flow, are the underlying cause of many forms of CKD. One of the key proteins involved in maintaining proper vasodilation and function is the ABCC2, a member of the ATP binding cassette (ABC) family. In this article, we will discuss the ABCC2 protein, its function in the regulation of blood vessel diameter, and its potential as a drug target and biomarker for the treatment of CKD.

Introduction:

CKD is a complex condition that refers to a range of diseases and disorders characterized by decreased kidney function. CKD can be divided into several stages, including chronic kidney disease (CKD1), acute kidney injury (CKD2), and end-stage renal disease (ESRD). The leading cause of CKD is the chronic form, which is associated with an increased risk of developing cardiovascular diseases and other morbidities.

The vasculature plays a crucial role in maintaining proper kidney function. The vasculature is responsible for delivering oxygen and nutrients to the kidneys, as well as removing waste products and excess fluid. The smooth muscle in the vasculature plays a key role in maintaining the diameter of the blood vessels, allowing for proper blood flow to the kidneys. The ABCC2 protein is involved in the regulation of this diameter control mechanism.

Function and Interaction of ABCC2:

ABCC2 is a member of the ABC family, which includes several related proteins that are involved in various cellular processes, including

Protein Name: ATP Binding Cassette Subfamily C Member 2

Functions: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine (PubMed:10220572, PubMed:11500505)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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