CCDC63: An Emerging Drug Target for Various Diseases (G160762)

Target Name: CCDC63

NCBI ID: G160762

CCDC63

CCDC63: An Emerging Drug Target for Various Diseases

Introduction

In the field of biomedical research, the identification of effective drug targets has remained a critical aspect in the development of therapeutic interventions. As our understanding of disease mechanisms expands, so does the opportunity to identify and exploit new targets for drug discovery. One such emerging target is CCDC63, a protein involved in several pathological processes. In this article, we will delve deeper into the various aspects of CCDC63 as a drug target and its implications for different diseases.

What is CCDC63?

CCDC63, also known as Coiled-Coil Domain Containing 63, is a protein encoded by the CCDC63 gene. It is predominantly found in human cells and displays a highly conserved coiled-coil domain structure. Coiled-coil domains are known for their involvement in protein-protein interactions, making CCDC63 an intriguing candidate for its potential role in various cellular processes.

The Role of CCDC63 in Biological Pathways

Research has shown that CCDC63 plays a crucial role in various biological pathways, including cell division, intracellular transport, cilia formation, and DNA repair. These pathways have direct implications in the pathogenesis of different diseases, leading to the exploration of CCDC63 as a potential drug target.

1. Cell Division: CCDC63 has been found to be involved in regulating cell division. It interacts with other cell cycle proteins, contributing to the proper alignment and segregation of chromosomes during mitosis. Dysregulation of CCDC63 in cell division can lead to aberrant cell growth and proliferation, a hallmark of cancer. Consequently, targeting CCDC63 could potentially hinder tumor growth and progression.

2. Intracellular Transport: CCDC63 is also implicated in intracellular transport processes. It plays a role in regulating the trafficking of cargo proteins, such as growth factor receptors and ion channels. Dysfunctional intracellular transport can disrupt vital cellular communication and contribute to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. By targeting CCDC63, it might be possible to restore proper cellular transport processes and ameliorate disease progression.

3. Cilia Formation: Cilia are microtubule-based organelles found on the surface of many cell types. They play crucial roles in sensory perception, cellular motility, and signaling pathways. CCDC63 is involved in cilia formation and maintenance, and defects in cilia structure and function have been linked to various diseases termed ciliopathies. By targeting CCDC63, it may be possible to restore proper cilia function and thereby alleviate symptoms associated with ciliopathies.

4. DNA Repair: DNA damage can occur due to both environmental factors and errors during DNA replication. CCDC63 has been identified as a component of the DNA repair machinery, specifically involved in the repair of double-strand breaks. Dysfunctional DNA repair mechanisms can lead to the accumulation of genetic mutations and increase the risk of cancer development. Targeting CCDC63 may help enhance DNA repair processes and reduce the risk of genomic instability.

Targeting CCDC63 for Therapeutic Intervention

The involvement of CCDC63 in multiple disease-related pathways presents an attractive opportunity for therapeutic intervention. Numerous research studies have focused on identifying small molecules or compounds that can selectively modulate CCDC63 activity or protein-protein interactions.

One approach is to develop small molecule inhibitors that bind to CCDC63 and disrupt its interactions with specific partner proteins. By preventing these interactions, the downstream consequences of CCDC63 dysregulation may be mitigated. These inhibitors could potentially be used in various diseases where CCDC63 plays a role, such as cancer, neurodegenerative disorders, and ciliopathies.

Another approach involves utilizing gene therapy techniques to modulate CCDC63 expression levels. The use of viral vectors or CRISPR-Cas9 technology can mediate targeted gene knockdown or overexpression, allowing researchers to study the consequences of altered CCDC63 levels in disease models. Such gene therapy approaches hold promise for precision medicine, providing tailored treatments based on an individual's CCDC63 profile.

The Future of CCDC63 as a Biomarker and Drug Target

As research into CCDC63 advances, the potential for it to become an essential biomarker and drug target becomes increasingly evident. Given its involvement in multiple disease-related pathways, as outlined above, CCDC63 may serve as a valuable biomarker for disease diagnosis, prognosis, and monitoring therapeutic responses. Additionally, the development of specific CCDC63-targeting therapeutics holds promise for treating a range of diseases more effectively and with fewer adverse effects.

In conclusion, CCDC63 represents an emerging drug target that warrants further investigation. Its involvement in diverse pathological processes makes it an attractive candidate for therapeutic intervention. As our understanding of CCDC63 and its interactions deepens, we may witness the development of novel treatment strategies that could have significant impacts on various diseases, ultimately benefiting patients worldwide.

Protein Name: Coiled-coil Domain Containing 63

Functions: Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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