Target Name: DDOST
NCBI ID: G1650
Review Report on DDOST Target / Biomarker Content of Review Report on DDOST Target / Biomarker
DDOST
Other Name(s): Dolichyl-diphosphooligosaccharide-protein glycosyltransferase | Dolichyl-diphosphooligosaccharide-protein glycotransferase | oligosaccharyltransferase subunit 48 | oligosaccharyl transferase 48 kDa subunit | Oligosaccharyltransferase 48 kDa subunit | OST48 | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | KIAA0115 | oligosaccharyltransferase 48 kDa subunit | Oligosaccharide transferase | dolichyl-diphosphooligosaccharide-protein glycotransferase | OTTHUMP00000002882 | Dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase | OST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | GATD6 | OKSWcl45 | Asparagine N-glycosyltransferase; dolichyldiphosphooligosaccharide-protein | Oligosaccharyl transferase 48 kDa subunit | WBP1 | AGER1 | advanced glycation end-product receptor 1 | OST48_HUMAN | Advanced glycation endproduct receptor 1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor | Oligomannosyltransferase | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | DDOST 48 kDa subunit | advanced glycation endproduct receptor 1 | MGC2191 | CDG1R

Drug Development Opportunities for DDOST: A Potential Drug Target and Biomarker

DDOST (double-stranded DNA fragment) is a potential drug target and biomarker that has been identified through various studies. It is a unique DNA fragment that is derived from the exon region of a gene and has been shown to have anti-inflammatory and neuroprotective effects. In this article, we will discuss the potential drug development opportunities for DDOST as a drug target and biomarker.

Drug Target

DDOST has been shown to have a wide range of potential drug development applications as a protein. It can be used as a monoclonal antibody (mAb) target for treating various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. One of the advantages of using DDOST as a protein target is its high stability and the ability to generate antibodies with high affinity and specificity.

DDOST has also been shown to have potential as a small molecule inhibitor. It can be used to treat various diseases, including cancer, neurodegenerative disorders, and autoimmune disorders. The inhibition of DDOST has been shown to lead to the inhibition of the associated signaling pathways, which can result in the regression of the disease.

Biomarker

DDOST has also been shown to have potential as a biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune disorders. Its unique structure and the ability to generate antibodies with high affinity and specificity make it an attractive candidate for use as a biomarker.

One of the potential benefits of using DDOST as a biomarker is its ability to provide information about the disease progression and response to treatment. It can be used to monitor the disease and make decisions about the treatment plan.

Competitive Advantage

DDOST has several competitive advantages as a drug target and biomarker. One of the main advantages is its stability, which allows it to be used as a protein target or inhibitor. It is also a single fragment, which makes it easy to produce and store.

Another advantage of DDOST is its ability to generate antibodies with high affinity and specificity. This makes it an attractive candidate for use as a monoclonal antibody (mAb) target for treating various diseases.

DDOST has also been shown to have potential as a small molecule inhibitor. The inhibition of DDOST has been shown to lead to the inhibition of the associated signaling pathways, which can result in the regression of the disease. This makes it an attractive candidate for use as a biomarker for various diseases.

Conclusion

In conclusion, DDOST has a wide range of potential drug development applications as a protein and biomarker. Its unique structure and the ability to generate antibodies with high affinity and specificity make it an attractive candidate for use as a monoclonal antibody (mAb) target for treating various diseases. Its stability and the ability to generate antibodies with high affinity and specificity also make it an attractive candidate for use as a small molecule inhibitor. Further research is needed to fully understand the potential of DDOST as a drug target and biomarker.

Protein Name: Dolichyl-diphosphooligosaccharide--protein Glycosyltransferase Non-catalytic Subunit

Functions: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853)

The "DDOST Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDOST comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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