Target Name: DPH1
NCBI ID: G1801
Review Report on DPH1 Target / Biomarker Content of Review Report on DPH1 Target / Biomarker
DPH1
Other Name(s): Ovarian cancer-associated gene 1 protein | S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 | Diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 | diphtheria toxin resistance protein 1 | DPH2L1 | Ovarian tumor suppressor candidate 1 | DPH1 homolog (S. cerevisiae) | DPH1_HUMAN | DEDSSH | Diphthamide biosynthesis protein 2 homolog-like 1 | OVCA1 | Diphthamide biosynthesis protein 2-like | Candidate tumor suppressor in ovarian cancer 1 | Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1 | DPH2L | diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1 | diphthamide biosynthesis 1 | candidate tumor suppressor in ovarian cancer 1 | Diphtheria toxin resistance protein 1 | DPH1 homolog | diphthamide biosynthesis protein 1 | ovarian tumor suppressor candidate 1 | ovarian cancer-associated gene 1 protein | DPH2-like 1 | Diphthamide biosynthesis protein 1 | DPH-like 1 | diphthamide biosynthesis protein 2 homolog-like 1 | HsDph1

DPH1: A Promising Drug Target / Biomarker

Domain-specific proteins (DSPs) are a class of proteins that play a crucial role in various biological processes. One of the well-known DSPs is DPH1, which is a protein that is expressed in various tissues of the body. DPH1 is known to be involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, DPH1 has become an attractive drug target for researchers to study and develop new treatments.

D PH1: Structure and Function

DPH1 is a 21-kDa protein that is expressed in various tissues of the body, including the brain, heart, liver, and muscle. It is a member of the tyrosine kinase family 1 (TK1) and is characterized by the presence of a distinct N-terminal tyrosine residue and a catalytic C-terminus.

DPH1 functions as a critical regulator of cell proliferation, differentiation, and survival. It is involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. DPH1 has been shown to play a key role in the development of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

DPH1 has also been shown to be involved in the development and progression of cancer. It has been shown to promote the growth and survival of various cancer cell types, including human breast cancer cells and colon cancer cells.

DPH1 has also been shown to play a key role in the development and progression of autoimmune disorders. It has been shown to contribute to the development of rheumatoid arthritis, a common autoimmune disorder.

D PH1 Interactions

DPH1 has several interactions with other proteins that are involved in various cellular processes. One of the most significant interactions is with the protein known as PDGF-尾. PDGF-尾 is a cytokine that plays a critical role in the development and maintenance of tissues, including the brain. It is shown to interact with DPH1 and to promote the growth and survival of DPH1-expressing cells.

DPH1 has also been shown to interact with several other proteins, including TGF-β1, NF-kappa-B, and AP-1. TGF-β1 is a cytokine that plays a critical role in the development and maintenance of tissues, including the liver. It is shown to interact with DPH1 and to promote the growth and survival of DPH1-expressing cells.

D PH1 Signaling

DPH1 is involved in several signaling pathways that are important for the development and progression of various diseases. One of the most significant signaling pathways is the tyrosine signaling pathway. DPH1 is shown to play a key role in the regulation of tyrosine signaling, which is involved in the development and progression of various diseases.

D PH1 has been shown to regulate the tyrosine signaling pathway by interacting with several proteins, including PDGF-尾, TGF-β1, and NF-kappa-B. These proteins are involved in the regulation of cell proliferation, differentiation, and survival, and are critical for the development and progression of various diseases.

D PH1 Targets

DPH1 is a drug target that has been shown to be involved in the development and progression of various diseases. As a result, several compounds have been developed to target DPH1 and to prevent its activity. These compounds include small molecules, peptides, and antibodies.

One of the most promising compounds is a small molecule called P1-16, which is a inhibitor of the tyrosine signaling pathway. P1-16 has been shown to inhibit the growth and survival of DPH1-

Protein Name: Diphthamide Biosynthesis 1

Functions: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:30877278). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:10519411)

The "DPH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DPH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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DPH2 | DPH3 | DPH3P1 | DPH5 | DPH5-DT | DPH6 | DPH6-DT | DPH7 | DPM1 | DPM2 | DPM3 | DPP10 | DPP10-AS1 | DPP3 | DPP3-DT | DPP4 | DPP6 | DPP7 | DPP8 | DPP9 | DPP9-AS1 | DPPA2 | DPPA2P3 | DPPA3 | DPPA3P1 | DPPA3P2 | DPPA4 | DPPA4P3 | DPPA5 | DPPA5P4 | DPRX | DPRXP2 | DPRXP4 | DPT | DPY19L1 | DPY19L1P1 | DPY19L2 | DPY19L2P1 | DPY19L2P2 | DPY19L2P3 | DPY19L2P4 | DPY19L3 | DPY19L3-DT | DPY19L4 | DPY30 | DPYD | DPYD-AS1 | DPYS | DPYSL2 | DPYSL3 | DPYSL4 | DPYSL5 | DQX1 | DR1 | DRAIC | DRAM1 | DRAM2 | DRAP1 | DRAXIN | DRB sensitivity-inducing factor complex | DRC1 | DRC3 | DRC7 | DRD1 | DRD2 | DRD3 | DRD4 | DRD5 | DRD5P1 | DRD5P2 | DRG1 | DRG2 | DRGX | DRICH1 | DROSHA | DRP2 | DSC1 | DSC2 | DSC3 | DSCAM | DSCAM-AS1 | DSCAML1 | DSCC1 | DSCR10 | DSCR4 | DSCR8 | DSCR9 | DSE | DSEL | DSEL-AS1 | DSG1 | DSG1-AS1 | DSG2 | DSG3 | DSG4 | DSN1 | DSP | DSP-AS1 | DSPP | DST