EIF4A2: A Drug Target / Disease Biomarker (G1974)

Target Name: EIF4A2

NCBI ID: G1974

EIF4A2

EIF4A2: A Drug Target / Disease Biomarker

EIF4A2, also known as EIF4A, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the eukaryotic Initiation Factor (EIF) complex, which is a protein that plays a critical role in the initiation of cell signaling pathways. EIF4A2 has been shown to be involved in a variety of cellular processes, including cell signaling, DNA replication, and stress response. As a result, EIF4A2 has potential as a drug target or biomarker.

The EIF4A2 protein is composed of 1,942 amino acids and has a calculated molecular mass of 21.9 kDa. It is expressed in a variety of tissues, including muscle, heart, liver, and brain. EIF4A2 is primarily localized to the endoplasmic reticulum (ER), a structure that is responsible for the quality control and summary of the cell's genetic information. EIF4A2 is also found in the cytoplasm, which is the fluid that surrounds the cells.

One of the key functions of EIF4A2 is its role as a regulator of the EIF4A complex. The EIF4A complex is a protein that is composed of the EIF4A protein and several other proteins that work together to regulate the initiation of cell signaling pathways. EIF4A2 is the main structural component of the EIF4A complex and is responsible for its stability and function.

In addition to its role in the EIF4A complex, EIF4A2 has also been shown to be involved in a variety of other cellular processes. For example, EIF4A2 has been shown to be involved in cell signaling, particularly in the regulation of cell proliferation. In addition, EIF4A2 has been shown to be involved in DNA replication, particularly in the regulation of the DNA replication complex.

EIF4A2 has also been shown to be involved in stress response, particularly in the regulation of cellular stress responses. In addition, EIF4A2 has been shown to be involved in the regulation of cellular adhesion, which is the process by which cells stick together to form tissues and organs.

Given its involvement in a variety of cellular processes, EIF4A2 has potential as a drug target or biomarker. For example, EIF4A2 could be targeted by drugs that are designed to inhibit its activity, such as small molecules or antibodies. In addition, EIF4A2 could be used as a biomarker to diagnose or monitor a variety of diseases, such as cancer, heart disease, or neurological disorders.

Overall, EIF4A2 is a protein that is expressed in a variety of tissues and is involved in a variety of cellular processes. As a result, it has potential as a drug target or biomarker. Further research is needed to fully understand the role of EIF4A2 in cell signaling and to determine its potential as a therapeutic agent.

Protein Name: Eukaryotic Translation Initiation Factor 4A2

Functions: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon

The "EIF4A2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EIF4A2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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