Identifying Potential Drug Targets for NT5M (G56953)

Target Name: NT5M

NCBI ID: G56953

NT5M

Identifying Potential Drug Targets for NT5M

Nucleotidase (NT) is an enzyme that is involved in the DNA replication process in all living organisms. Mitochondria, the powerhouses of eukaryotic cells, require DNA replication to produce the energy-carrying molecules (nucleotides), such as DNA, RNA, and protein . The nuclear replication process is tightly controlled by a complex network of enzymes, including the DNA polymerase complex, which is composed of the enzyme DNA polymerase (DNAP), the single-stranded DNA binding protein SSB, and the double-stranded DNA binding protein Dp.

The 5'-nucleotidase (NT5M) is a crucial enzyme in the DNA replication process in mitochondria. It is an essential component of the NDEL (nucleotidase-driven endonuclease) family, which is responsible for the breakdown of double-stranded DNA at the 5 ' end. In addition to its role in DNA replication, NT5M has also been shown to play a significant role in various cellular processes, including cell growth, apoptosis, and metabolism.

Drug Targeting

NT5M has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. The NT5M enzyme has a distinct 3D structure, with a catalytic core composed of a parallel beta-sheet and a transmembrane region that is responsible for its unique stability and stability. This 3D structure makes it a potential target for small molecules, such as inhibitors, that can disrupt the activity of the enzyme.

In addition to its structural features, NT5M has also been shown to play a significant role in various cellular processes. For example, NT5M has been shown to be involved in the regulation of cell growth and apoptosis. In addition, NT5M has also been shown to play a significant role in the regulation of metabolism, including the metabolism of fatty acids and the tricarboxylic acid (TCA) cycle.

Biomarker

The detection of NT5M in biological tissues, cells or biological fluids can be used as biomarkers for drug research. Since NT5M is considered a critical stage of cell growth and cell division in the S phase, G2 phase and M phase of the cell cycle, its high level expression in biological tissues, cells or biological fluids can be used to evaluate the effects of drugs on the cell cycle and growth. of biomarkers. In addition, since NT5M plays a role in apoptosis, metabolism, and inflammatory responses, its high-level expression in biological tissues, cells, or biological fluids can also be used as a biological indicator to evaluate the effects of drugs on apoptosis, metabolism, and inflammatory responses. landmark.

Conclusion

NT5M is an enzyme involved in the DNA replication process in all cells. High-level expression in biological tissues, cells or biological fluids can be used as a biomarker for drug research. Its 3D structure, various processes involved in cell cycle and growth, metabolism, and its properties as a drug target make it a promising drug target. With the continuous development of science and technology, more effective drugs are expected to be developed in the future to treat various diseases related to NT5M.

Protein Name: 5',3'-nucleotidase, Mitochondrial

Functions: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

The "NT5M Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NT5M comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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