NUBP2: A Potential Drug Target and Biomarker (G10101)

Target Name: NUBP2

NCBI ID: G10101

NUBP2

NUBP2: A Potential Drug Target and Biomarker

Nucleotide-binding proteins (NSPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including DNA replication, transcription, and signaling. One of the NSPs that has garnered significant interest in recent years is NUBP2, an NSP that is expressed in various tissues and has been shown to play important roles in several biological processes, including cell growth, differentiation, and inflammation.

NUBP2 is a 21-kDa protein that is composed of a unique transmembrane region and a cytoplasmic tail. The transmembrane region of NUBP2 is made up of a single sheet of 126 amino acid residues that is held together by 11 interactions with various nucleotides, including DNA, RNA, and proteins. The cytoplasmic tail of NUBP2 is made up of a 165 amino acid long tail that is involved in several cellular processes, including the regulation of cell adhesion and the production of adenosine, a signaling molecule that plays important roles in inflammation and stress responses.

One of the key functions of NUBP2 is its role in cell adhesion. NUBP2 has been shown to be involved in the regulation of cell-cell adhesion, as well as cell-cell interactions with the extracellular matrix (ECM). This is important for several cellular processes, including tissue formation, embryonic development, and cancer progression. In addition, NUBP2 has also been shown to play a role in the regulation of cell migration, which is critical for the development of cancer and other diseases.

Another important function of NUBP2 is its role in inflammation and stress responses. NUBP2 has been shown to play a critical role in the regulation of inflammation and stress responses, as well as the production of adenosine. Adenosine is a signaling molecule that plays important roles in the regulation of inflammation, pain, and stress responses. In addition, NUBP2 has also been shown to be involved in the regulation of cellular stress responses, including the regulation of cell cycle progression and the production of reactive oxygen species (ROS).

In addition to its role in cell adhesion and stress responses, NUBP2 has also been shown to play a critical role in several other cellular processes, including cell growth, differentiation, and protein synthesis. NUBP2 has been shown to be involved in the regulation of cellular signaling pathways, including the TGF-β pathway, which is involved in cell growth and differentiation, as well as the PI3K/Akt pathway, which is involved in the regulation of protein synthesis and cell survival.

Given the significance of NUBP2's role in several important cellular processes, it is not surprising that NUBP2 has been identified as a potential drug target. Several studies have shown that NUBP2 can be targeted by small molecules, including inhibitors of tyrosine kinase activity, which is a common signaling pathway involved in the regulation of many cellular processes. In addition, NUBP2 has also been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In conclusion, NUBP2 is a protein that has significant roles in several important cellular processes, including cell adhesion, stress responses, and protein synthesis. Its unique transmembrane and cytoplasmic tail make it an attractive target for small molecules, and its involvement in several diseases make it a promising biomarker for diagnostic and therapeutic applications. Further research is needed to fully understand the role of NUBP2 in cellular processes and its potential as a drug target.

Protein Name: NUBP Iron-sulfur Cluster Assembly Factor 2, Cytosolic

Functions: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure

The "NUBP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUBP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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