SEC61G: A Potential Drug Target for Protein Translation and Cellular Signaling

Target Name: SEC61G

NCBI ID: G23480

SEC61G

SEC61G: A Potential Drug Target for Protein Translation and Cellular Signaling

SEC61G, also known as SEC61 translocon subunit gamma, transcript variant 1, is a protein that is expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein translation in eukaryotic cells. The SEC61G protein has been identified as a potential drug target and has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SEC61G is a member of the SEC61 family of proteins, which are known to play a role in the regulation of protein synthesis in eukaryotic cells. The SEC61 family consists of six proteins, including SEC61A, SEC61B, SEC61C, SEC61D, SEC61E, and SEC61F. These proteins are characterized by the presence of a catalytic alpha-helices and a nucleotide-binding domain, which is responsible for the protein's stability and function.

SEC61G is unique among the SEC61 proteins in that it is the only one that is expressed in the ER and is involved in the regulation of protein translation. The ER is a specialized organelle that is responsible for the folding and processing of proteins before they are released into the cytoplasm. The ER plays a crucial role in the regulation of protein translation by ensuring that incoming proteins are processed and fold correctly before they are translated into functional proteins.

SEC61G is also involved in the regulation of protein translation by helping to ensure that the ribosome, which is the machine that reads the DNA code and translates it into a protein, is assembled properly and functions correctly. by helping to ensure that the ribosome is properly primed and has the necessary components to begin the translation process.

In addition to its role in protein translation, SEC61G is also involved in the regulation of protein stability and degradation. SEC61G helps to ensure that proteins that are synthesized are properly folded and stable, and that they are properly degraded when they are no longer needed. This helps to prevent the accumulation of damaged or unnecessary proteins in the cell, which can contribute to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SEC61G is also involved in the regulation of cellular signaling pathways. SEC61G is a negative regulator of the TOR signaling pathway, which is a critical pathway that regulates cell growth, metabolism, and stress responses. The TOR signaling pathway is activated when the cell is challenged or stressed, and it helps the cell to respond to these challenges by promoting protein synthesis, cell growth, and inflammation. By serving as a negative regulator of the TOR signaling pathway, SEC61G helps to prevent the cell from becoming too active or over-stimulated in response to these challenges.

In conclusion, SEC61G is a protein that is involved in the regulation of protein translation and stability in eukaryotic cells. It is a potential drug target and has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of SEC61G in the regulation of protein synthesis and cellular signaling pathways.

Protein Name: SEC61 Translocon Subunit Gamma

Functions: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity)

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