SELENON: A Review on a Potential Drug Target and Biomarker (G57190)

Target Name: SELENON

NCBI ID: G57190

SELENON

SELENON: A Review on a Potential Drug Target and Biomarker

Selenon, derived from the Greek word selenon, meaning moon, is a term that has been used in various scientific contexts to describe a protein that is composed of two distinct regions: a N-terminal region containing a highly conserved aryl hydrocarbon (AH) domain and a C-terminal region containing a helix-loop structure. Selenon proteins have been identified in various organisms, including bacteria, archaea, and eukaryotes, and are involved in various cellular processes, including DNA replication, transcription, and repair, as well as cell signaling pathways.

Recently, researchers have discovered that selenon proteins play a crucial role in the regulation of gene expression and have identified several potential drug targets. One of these drug targets is the serotonin receptor, which is a G protein-coupled receptor that plays a central role in sensory perception, mood regulation, and other physiological processes. The serotonin receptor is composed of an extracellular portion, known as the receptor complex, and an intracellular portion, known as the transmembrane region.

The N-terminal region of the selenon protein contains a highly conserved AH domain, which is known to be involved in the regulation of protein-protein interactions and is thought to play a role in the regulation of the serotonin receptor. The C-terminal region of the selenon protein contains a helix-loop structure that is thought to be involved in the regulation of protein stability and may be involved in the regulation of the serotonin receptor.

Selenon has been shown to interact with several serotonin receptors, including the 5-HT2A receptor, which is a G protein-coupled receptor that is involved in pain perception and other physiological processes. The interaction between Selenon and the 5-HT2A receptor has been shown to play a role in the regulation of pain perception and may be a potential drug target for the treatment of chronic pain.

In addition to its potential role in the regulation of serotonin receptors, selenon has also been shown to be involved in the regulation of other physiological processes. For example, selenon has been shown to be involved in the regulation of cell adhesion, cell migration, and the association of DNA with histone modifications.

Selenon has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, selenon has been shown to be overexpressed in several types of cancer, including breast, ovarian, and colorectal cancer. This increase in selenon expression may contribute to the development and progression of these diseases.

In conclusion, Selenon is a protein that has been identified in various organisms and is involved in various cellular processes. The N-terminal and C-terminal regions of Selenon contain unique domains that are involved in the regulation of protein-protein interactions and the regulation of protein stability, respectively. Recently, researchers have discovered that selenon is involved in the regulation of serotonin receptors and has been shown to interact with several of these receptors, including the 5-HT2A receptor. In addition, selenon has also been shown to be involved in the regulation of cell adhesion, cell migration, and the association of DNA with histone modifications, as well as the regulation of pain perception.

Furthermore, selenon has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. The increasing interest in the role of selenon in these diseases may lead to the development of new therapeutic approaches for the treatment of these diseases.

Overall, Selenon is a protein that has significant potential as a drug target and biomarker. Further research is needed to fully understand its role in various biological processes and to develop new therapeutic approaches for the treatment of diseases associated with its dysfunction.

Protein Name: Selenoprotein N

Functions: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863)

The "SELENON Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SELENON comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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