Selenoprotein P: A Protein Modulator of Visual Function and Cell Signaling in The Retina

Target Name: SELENOP

NCBI ID: G6414

SELENOP

Selenoprotein P: A Protein Modulator of Visual Function and Cell Signaling in The Retina

SELENOPRte transcript variant 1, also known as SELENOPRte-P, is a gene that encodes a protein known as Selenoprotein P (SPP). SPP is a protein that is expressed in the retina, which is the part of the eye responsible for transmitting light to the brain. It is one of several proteins that are known as modulators of the visual field, meaning that they can affect the way the brain interprets the visual information that it receives.

Selenoprotein P is a 19 kilobase (kb) protein that contains 166 amino acids. It is made up of a single polypeptide chain that is composed of four distinct regions: an N-terminus, a catalytic domain, a transmembrane region, and a C-terminus. The N-terminus of SPP is the region that is involved in its cell surface localization and interactions, while the catalytic domain is the region that contains the protein's active site, which is responsible for catalyzing chemical reactions. The transmembrane region is the region that spans the entire width of the cell membrane and is involved in SPP's intracellular signaling functions. The C-terminus of SPP is the region that contains the protein's carboxylic acid residue, which is involved in its stability and interactions with other proteins.

SPP is expressed in the retina and is involved in several important functions, including:

1. Visual perception: SPP is one of several proteins that are known as modulators of the visual field, meaning that it can affect the way the brain interprets the visual information that it receives. It is involved in the perception of light, dark, and color, as well as the spatial organization of visual information in the brain.
2. Cell signaling: SPP is involved in several signaling pathways that are important for the development and maintenance of the retina. It is part of the TGF-β pathway, which is a well-known signaling pathway that is involved in the regulation of cell growth, differentiation, and survival.
3. Maintenance of retinal homeostasis: SPP is involved in several processes that are important for maintaining the homeostasis of the retina, including the regulation of ion homeostasis, the maintenance of plasma membrane tightness, and the regulation of neurotransmitter signaling.

Due to its involvement in several important functions, SPP is a potential drug target for a variety of diseases. For example, it is thought to be involved in the development and progression of age-related macular degeneration (AMD), which is the leading cause of blindness in the elderly. It is also involved in the regulation of the growth and differentiation of photoreceptor cells, which are responsible for transmitting visual information from the retina to the brain.

SPP is also a potential biomarker for several diseases, including AMD, diabetic retinopathy, and age-related macular degeneration. For example, it has been shown to be elevated in the blood of patients with AMD, and it has also been used as a biomarker for the diagnosis of diabetic retinopathy, a common complication of diabetes that can lead to blindness.

In conclusion, SELENOPRte transcript variant 1 (SPP) is a gene that encodes a protein that is involved in several important functions in the retina, including visual perception, cell signaling, and maintenance of retinal homeostasis. It is a potential drug target and biomarker for a variety of diseases, including AMD, diabetic retinopathy, and age-related macular degeneration. Further research is needed to fully understand the role of SPP in these diseases and to develop effective treatments.

Protein Name: Selenoprotein P

Functions: Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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