MACF1: A Potential Drug Target for Eye and Brain Diseases (G23499)

Target Name: MACF1

NCBI ID: G23499

MACF1

MACF1: A Potential Drug Target for Eye and Brain Diseases

MACF1, also known as trabeculin-alpha, is a protein that is expressed in the retina of the eye. It is a member of the superfamily of cytoplasmic retinol-coiled-coiled (CR-CO) proteins, which are characterized by the presence of a cytoplasmic tail that is composed of a repeating sequence of alpha helices. MACF1 is a 12-kDa protein that is predominantly localized to the outer layer of the retina, and it is involved in the development and maintenance of the retinal blood vessels.

Recent studies have identified MACF1 as a potential drug target for the treatment of a variety of diseases, including cancer, neurodegenerative diseases, and diseases of the eye. This is because MACF1 is involved in the formation of blood vessels, which are critical for the delivery of oxygen and nutrients to the retina, and it is also involved in the removal of waste products from the retina. As a result, changes in MACF1 expression levels have been observed in a variety of diseases, including age-related macular degeneration (AMD) , diabetic retinopathy, and neurodegenerative diseases.

One of the reasons why MACF1 has been identified as a potential drug target is because it is a protein that is expressed in the retina, which makes it a potential therapeutic target for diseases that affect the retina. In addition, MACF1 is involved in the development and maintenance of the retinal blood vessels, which makes it a potential target for diseases that affect the blood vessels in the retina. This is an important consideration because many diseases that affect the retina, such as AMD and diabetic retinopathy, are caused by changes in the blood vessels in the retina.

Another reason why MACF1 has been identified as a potential drug target is because it is a protein that is involved in the formation of blood vessels. This is an important consideration because many diseases that affect the blood vessels, such as heart disease and cancer, are caused by changes in the blood vessels. In addition, MACF1 is involved in the delivery of oxygen and nutrients to the retina, which makes it a potential target for diseases that affect the delivery of oxygen and nutrients to the retina.

In addition to its role in the formation of blood vessels and the delivery of oxygen and nutrients to the retina, MACF1 is also involved in the development and maintenance of the retinal barrier. The retinal barrier is a layer of cells that separates the retina from the retina underlying choroid layer, and it helps to protect the retina from the harmful effects of the surrounding environment. MACF1 is involved in the development and maintenance of the retinal barrier, which makes it a potential target for diseases that affect the retinal barrier.

MACF1 has also been identified as a potential biomarker for a variety of diseases, including cancer and neurodegenerative diseases. This is important because it can be used as a diagnostic tool for diseases that affect the retina, such as AMD and diabetic retinopathy. In addition, MACF1 has been shown to be involved in the development and progression of a variety of neurodegenerative diseases, which makes it a potential target for therapies that can slow down or stop the progression of these diseases.

In conclusion, MACF1 is a protein that is expressed in the retina and is involved in the development and maintenance of blood vessels, the formation of the retinal barrier, and the delivery of oxygen and nutrients to the retina. As a result, MACF1 has been identified as a potential drug target for the treatment of a variety of diseases, including cancer, neurodegenerative diseases, and diseases of the eye. Additionally, MACF1 has also been identified as a potential biomarker for a variety of diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of MACF1 in the development and treatment of diseases.

Protein Name: Microtubule Actin Crosslinking Factor 1

Functions: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity)

The "MACF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MACF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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