MAD2L1: A Protein Regulator of Cell-Cell and Protein-Protein Interactions

Target Name: MAD2L1

NCBI ID: G4085

MAD2L1

MAD2L1: A Protein Regulator of Cell-Cell and Protein-Protein Interactions

MAD2L1 (MutL homolog 2-like 1), also known as HSMAD2 (HSP90-associated protein 2), is a protein that plays a critical role in various cellular processes. MAD2L1 is a highly conserved protein that is expressed in many different tissues and cells, including the brain, pancreas, and gastrointestinal tract.

One of the most significant functions of MAD2L1 is its role in the regulation of cell-cell interactions and protein-protein interactions. MAD2L1 is a protein that can interact with a wide range of proteins, including its own cognate protein, HSP90. HSP90 is a protein that is known for its ability to interact with a wide range of proteins, including transcription factors, thereby participating in the regulation of various cellular processes.

MAD2L1 has also been shown to play a role in the regulation of cell growth and differentiation. MAD2L1 has been shown to interact with the transcription factor, p53, and to regulate the expression of various genes involved in cell growth and differentiation.

In addition to its role in cell-cell and protein-protein interactions, MAD2L1 has also been shown to play a critical role in the regulation of various cellular processes involved in cell death and stress. MAD2L1 has been shown to interact with the protein, Bcl-2, and to regulate the expression of genes involved in cell death and stress.

MAD2L1 is also involved in the regulation of inflammation and immune responses. MAD2L1 has been shown to interact with the protein, NF-kappa-B, and to regulate the expression of genes involved in inflammation and immune responses.

MAD2L1 is a protein that has been shown to play a critical role in the regulation of various cellular processes, including cell-cell and protein-protein interactions, cell growth and differentiation, cell death and stress, and inflammation and immune responses. As a result, MAD2L1 has potential as a drug target or biomarker for a variety of diseases.

MAD2L1 has been shown to interact with a wide range of proteins, including its own cognate protein, HSP90. HSP90 is a protein that is known for its ability to interact with a wide range of proteins, including transcription factors, thereby participating in the regulation of various cellular processes.

One of the most significant functions of MAD2L1 is its role in the regulation of cell-cell interactions and protein-protein interactions. MAD2L1 is a protein that can interact with a wide range of proteins, including its own cognate protein, HSP90.

MAD2L1 has also been shown to play a role in the regulation of cell growth and differentiation. MAD2L1 has been shown to interact with the transcription factor, p53, and to regulate the expression of various genes involved in cell growth and differentiation.

In addition to its role in cell-cell and protein-protein interactions, MAD2L1 has also been shown to play a critical role in the regulation of various cellular processes involved in cell death and stress. MAD2L1 has been shown to interact with the protein, Bcl-2, and to regulate the expression of genes involved in cell death and stress.

MAD2L1 is also involved in the regulation of inflammation and immune responses. MAD2L1 has been shown to interact with the protein, NF-kappa-B, and to regulate the expression of genes involved in inflammation and immune responses.

In conclusion, MAD2L1 is a protein that has been shown to play a critical role in the regulation of various cellular processes, including cell-cell and protein-protein interactions, cell growth and differentiation, cell death and stress, and inflammation and immune responses. As a result, MAD2L1 has potential as a drug target or biomarker for a variety of diseases.

Protein Name: Mitotic Arrest Deficient 2 Like 1

Functions: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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