MAFF: A Non-Coding RNA Molecule Regulating Cell Growth, Differentiation and Inflammation

Target Name: MAFF

NCBI ID: G23764

MAFF

MAFF: A Non-Coding RNA Molecule Regulating Cell Growth, Differentiation and Inflammation

MAFF (MAF bZIP transcription factor F, transcript variant 1) is a non-coding RNA molecule that plays a critical role in the regulation of gene expression. It is a key transcription factor that is involved in the control of various biological processes, including cell growth, differentiation, and inflammation.

MAFF is a member of the bZIP transcription factor family, which includes a variety of transcription factors that are involved in the regulation of gene expression. These transcription factors are characterized by the presence of a bZIP domain, which is a key factor in the recruitment of DNA-binding proteins.

MAFF is a non-coding RNA molecule that is expressed in a variety of tissues and cells. It is highly expressed in the brain, where it is involved in the regulation of neural stem cell proliferation and the development of neural circuits. It is also expressed in other tissues, including muscle, heart, and liver.

MAFF is involved in the regulation of gene expression by binding to specific DNA sequences. It has been shown to play a role in the regulation of various biological processes, including cell growth, differentiation, and inflammation.

One of the key functions of MAFF is its role in the regulation of cell growth. MAFF has been shown to play a negative role in the regulation of cell growth by binding to the DNA molecule and preventing the access of DNA-binding proteins. This process is known as transcriptional repression, and it allows cells to maintain a controlled size and shape.

MAFF is also involved in the regulation of differentiation. During development, MAFF plays a critical role in the regulation of cell fate and the development of specific tissues. It has been shown to play a role in the regulation of the development of the nervous system, including the specification of neural stem cells into different neuron types.

MAFF is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of inflammatory responses by binding to the DNA molecule and preventing the access of DNA-binding proteins. This process is known as transcriptional repression, and it allows cells to maintain a controlled response to inflammation.

Despite its involvement in a variety of important biological processes, MAFF is not well understood. There is currently a lack of research on the molecular mechanisms that regulate MAFF expression and its function in these processes.

In conclusion, MAFF is a non-coding RNA molecule that plays a critical role in the regulation of gene expression. It is a key transcription factor that is involved in the control of various biological processes, including cell growth, differentiation, and inflammation. Further research is needed to understand the molecular mechanisms that regulate MAFF expression and its function in these processes.

Protein Name: MAF BZIP Transcription Factor F

Functions: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846)

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