Target Name: MAGI3
NCBI ID: G260425
Review Report on MAGI3 Target / Biomarker Content of Review Report on MAGI3 Target / Biomarker
MAGI3
Other Name(s): Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (isoform 1) | MAGI3 variant 1 | membrane-associated guanylate kinase-related 3 | MAGI-3 | Membrane associated guanylate kinase, WW and PDZ domain containing 3, transcript variant 1 | RP4-730K3.1 | OTTHUMP00000013457 | dJ730K3.2 | DJ730K3.2 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 | MAGI3 variant 2 | Membrane associated guanylate kinase, WW and PDZ domain containing 3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | MAGI3_HUMAN | Membrane associated guanylate kinase, WW and PDZ domain containing 3, transcript variant 2 | OTTHUMP00000013455 | membrane-associated guanylate kinase inverted 3 | Membrane-associated guanylate kinase-related 3 | Membrane-associated guanylate kinase inverted 3 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (isoform 2) | OTTHUMP00000013454 | MGC163281 | OTTHUMP00000013456 | KIAA1634

MAGI3: Membrane-associated Guanylate Kinase Involved in Various Cellular Processes

MAGI3, also known as Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (isoform 1), is a protein that plays a crucial role in various cellular processes. MAGI3 is a 21-kDa protein that is expressed in most tissues of the body. It is characterized by the presence of three domains: MAGI3-membrane, MAGI3-intracellular domain, and MAGI3-PDZ domain.

The MAGI3-membrane domain is the extracellular domain of MAGI3, which is involved in cell-cell adhesion and tissue-cell interactions. This domain is composed of a transmembrane region and an intracellular region that contains a putative cytoplasmic domain. The cytoplasmic domain is involved in the interaction between MAGI3 and various cellular signaling pathways.

The MAGI3-intracellular domain is the intracellular domain of MAGI3, which is involved in the regulation of cellular processes such as cell growth, apoptosis, and signaling pathways. This domain is composed of a N-terminal region, a C-terminal region, and a putative Z-terminal region. The N-terminal region contains a putative nucleotide-binding oligomerization (NBO) domain, which is involved in the regulation of DNA binding and gene expression. The C-terminal region contains a putative leucine-rich repeat (LRR) domain, which is involved in protein-protein interaction and is often involved in the regulation of cellular processes. The Z-terminal region contains a putative acid-binding domain, which is involved in acid-base regulation.

The MAGI3-PDZ domain is the PDZ domain-containing protein 3 (isoform 1) of MAGI3, which is involved in the regulation of cellular processes such as cell-cell adhesion, migration, and invasion. This domain is composed of a N-terminal region, a C-terminal region, and a putative Z-terminal region. The N-terminal region contains a putative nucleotide-binding oligomerization (NBO) domain, which is involved in the regulation of DNA binding and gene expression. The C-terminal region contains a putative leucine-rich repeat (LRR) domain, which is involved in protein-protein interaction and is often involved in the regulation of cellular processes. The Z-terminal region contains a putative acid-binding domain, which is involved in acid-base regulation.

MAGI3 is involved in various cellular processes, including cell-cell adhesion, migration, and invasion. It is also involved in the regulation of cellular signaling pathways such as the TGF-β pathway, the Wnt pathway, and theNotch pathway. MAGI3 is also involved in the regulation of cellular apoptosis, which is a critical regulation of cell death that is necessary for the development and maintenance of tissues and organs.

MAGI3 is also involved in the regulation of cellular processes such as cell growth, which is critical for the growth and development of tissues and organs. MAGI3 is also involved in the regulation of cellular interactions such as cell-cell adhesion, which is necessary for the development and maintenance of tissues and organs.

MAGI3 is also involved in the regulation of cellular signaling pathways such as the TGF-β pathway, the Wnt pathway, and theNotch pathway. These pathways are involved in the regulation of cellular processes such as cell growth, apoptosis, and

Protein Name: Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3

Functions: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2

The "MAGI3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAGI3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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