PRKD3: Key Regulator of ECM Degradation and Fibrosis (G23683)

Target Name: PRKD3

NCBI ID: G23683

PRKD3

PRKD3: Key Regulator of ECM Degradation and Fibrosis

PRKD3 (KPCD3_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, kidneys, and liver. It is a key regulator of the polyprotein Kallikrein-related peptidases (K-terminal peptidases) family, which is involved in the degradation of extracellular matrix (ECM) components and other proteins. In addition to its role in cell signaling, PRKD3 has also been shown to play a key role in the regulation of inflammation and fibrosis.

PRKD3 is a 21-kDa protein that consists of 126 amino acid residues. It has a molecular weight of 19,112 Da and a calculated pI of 4.95. PRKD3 is expressed in a variety of tissues and cells in the human body, including the brain, heart , kidneys, and liver. It is highly expressed in the liver, with lower levels found in the heart, kidneys, and brain.

One of the key functions of PRKD3 is its role in the regulation of the degradation of ECM components. ECM components, such as collagen and extracellular matrix (ECM) proteins, are constantly being degraded by enzymes such as PRKD3, in order to maintain the homeostasis of the body. The degradation of ECM components is important for maintaining tissue repair and regeneration, as well as for the regulation of cellular signaling pathways.

In addition to its role in ECM degradation, PRKD3 is also involved in the regulation of inflammation and fibrosis. It has been shown to play a key role in the regulation of chronic pain and inflammation, as well as in the development of fibrosis. PRKD3 has has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha and IL-1, and in the regulation of the production of anti-inflammatory cytokines, such as IL-10.

PRKD3 is also involved in the regulation of cellular signaling pathways that are important for cell survival and growth. It has been shown to play a key role in the regulation of cell adhesion, as well as in the regulation of cell proliferation and differentiation.

As a potential drug target, PRKD3 is an attractive target for drug development due to its involvement in a variety of important cellular processes that are important for human health and disease. In addition, its relatively small size and high expression make it an attractive target for small molecule inhibitors.

In conclusion, PRKD3 is a protein that is involved in a variety of important cellular processes that are important for human health and disease. Its role in the regulation of ECM degradation, inflammation, and fibrosis, as well as its involvement in cellular signaling pathways, make it an attractive target for drug development. Further research is needed to fully understand the mechanisms of PRKD3's role in these processes and to develop effective small molecule inhibitors.

Protein Name: Protein Kinase D3

Functions: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity)

The "PRKD3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRKD3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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