GABARAPL1: A Potential Drug Target and Biomarker (G23710)

Target Name: GABARAPL1

NCBI ID: G23710

GABARAPL1

GABARAPL1: A Potential Drug Target and Biomarker

GABARAPL1, also known as GEC1, is a gene that encodes a protein involved in the G-protein-coupled receptor (GPCR) signaling pathway. GPCR is a family of transmembrane proteins that play a crucial role in cellular signaling, including sensory perception, neurotransmission, and hormone signaling. GABARAPL1 is one of several GPCR genes that have been identified as potential drug targets in recent years.

The GPCR signaling pathway is a complex intracellular signaling system that involves the interaction of various protein components. The GPCR receptor is a key mediator of this signaling pathway, as it plays a critical role in transmitting signals from the cell surface to intracellular signaling pathways. The GPCR receptor is composed of a extracellular portion, a transmembrane segment, and an intracellular portion. The intracellular portion of the GPCR receptor is known as the co-receptor, which is responsible for interacting with the protein GABARAPL1.

GABARAPL1 is a 19-kDa protein that is expressed in various tissues and cells, including neurons, muscle cells, and the heart. It is characterized by a long N-terminus, a catalytic domain, and a short C-terminus. The catalytic domain of GABARAPL1 contains a catalytic cycle sequence that is known as the catalytic active site, which is responsible for the protein's catalytic activity.

GABARAPL1 functions as a scaffold protein, which can interact with various protein components of the GPCR signaling pathway. It has been shown to play a role in the regulation of neuronal excitability and neurotransmission. GABARAPL1 has been shown to interact with the protein PSD90, which is a known co-receptor for GABARAPL1. The interaction between GABARAPL1 and PSD90 has been shown to modulate the activity of the GPCR receptor, suggesting that GABARAPL1 may be a drug target for GPCR-mediated signaling pathways.

In addition to its role in the GPCR signaling pathway, GABARAPL1 has also been shown to play a role in the regulation of cellular processes such as cell adhesion, migration, and invasion. GABARAPL1 has been shown to interact with the protein Focal Adhesion Protein (FAP), which is involved in cell adhesion and migration. The interaction between GABARAPL1 and FAP has been shown to regulate the activity of the FAP/FAK signaling pathway, which is involved in the regulation of cell adhesion and migration.

GABARAPL1 has also been shown to play a role in the regulation of neurotransmission. GABARAPL1 has been shown to interact with the protein TrkB, which is involved in the regulation of neurotransmitter release. The interaction between GABARAPL1 and TrkB has been shown to modulate the activity of the TrkB/DAK signaling pathway, suggesting that GABARAPL1 may be a drug target for neurotransmission-mediated signaling pathways.

GABARAPL1 has also been shown to play a role in the regulation of cellular signaling pathways that are involved in aging and age-related diseases. GABARAPL1 has been shown to interact with the protein p53, which is involved in the regulation of DNA damage repair and cellular stress responses. The interaction between GABARAPL1 and p53 has been shown to modulate the activity of the p53/Tp53 signaling pathway, suggesting that GABARAPL1 may be a drug target for processes associated with aging and age-related diseases.

In conclusion, GABARAPL1 is a protein that has been shown to play a role in the GPCR signaling pathway, as well as in the regulation of neuronal excitability, neurotransmission, and cellular signaling pathways. Its potential as a drug target makes it an attractive target for research into the mechanisms of cellular signaling and the development of new therapeutic agents for a variety of diseases. Further research is needed to fully understand the role of GABARAPL1 in cellular signaling and its potential as a drug target.

Protein Name: GABA Type A Receptor Associated Protein Like 1

Functions: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537)

The "GABARAPL1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GABARAPL1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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