KCTD4: A Protein Essential for Heart and Muscle Function (G386618)

Target Name: KCTD4

NCBI ID: G386618

KCTD4

KCTD4: A Protein Essential for Heart and Muscle Function

KCTD4, also known as Potassium channel tetramerization domain containing 4, is a protein that plays a crucial role in the function of potassium channels in the heart. It is a member of the Tetramer subfamily of voltage-gated potassium channels, which are responsible for regulating the passage of electrical signals through the heart muscle.

KCTD4 is a transmembrane protein that spans the thickness of the cardiac myocytes. It is composed of four subunits that are held together by disulfide bonds. The subunits have different roles in the channel's function, including the regulation of channel opening and closure, as well as the control of channel conductivity.

One of the unique features of KCTD4 is its ability to form a homotetrameric complex with other K+ channels. This is important for the regulation of channel function, as it allows for the formation of channels that are homotypic and can interact with each other. The ability of KCTD4 to form homotetrameric channels also makes it a potential drug target in the future.

KCTD4 has also been shown to play a role in the regulation of muscle contractions in the heart. Studies have shown that KCTD4 is involved in the regulation of the rapid depolarization that occurs during the cardiac contraction phase. This is important for the regulation of the force that the heart muscle generates during contractions, and may be a potential target for drugs that are used to treat heart failure.

In addition to its role in the regulation of channel function, KCTD4 has also been shown to play a role in the regulation of cell survival. Studies have shown that KCTD4 is involved in the regulation of cell proliferation and survival in the cardiac myocytes. This is important for the regulation of the number and function of the cardiac myocytes, and may be a potential target for drugs that are used to prevent or treat cardiovascular disease.

KCTD4 is also a potential biomarker for the diagnosis of cardiac disease. Studies have shown that KCTD4 is expressed in the hearts of individuals with various conditions, including heart failure, hypertension, and myocardial infarction. This makes KCTD4 a potential target for diagnostic tools that can be used to diagnose these conditions.

In conclusion, KCTD4 is a protein that plays a crucial role in the function of potassium channels in the heart. Its ability to form a homotetrameric complex with other K+ channels and its involvement in the regulation of channel function, muscle contractions, and cell survival make it a potential drug target and biomarker for a variety of cardiovascular and neurological disorders. Further research is needed to fully understand the role of KCTD4 in the regulation of cardiovascular and neural systems.

Protein Name: Potassium Channel Tetramerization Domain Containing 4

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