A Potential Drug Target or Biomarker: Unlocking the Potential of KIAA0586 (Protein TALPID3 (isoform 7))

Target Name: KIAA0586

NCBI ID: G9786

KIAA0586

Other Name(s): Protein TALPID3 (isoform 7) | Protein TALPID3 (isoform 3) | Ortholog of chicken talpid{3} | KIAA0586, transcript variant 2 | KIAA0586 variant 6 | KIAA0586, transcript variant 1 | TALD3_HUMAN | KIAA0586 variant 1 | KIAA0586, transcript variant 7 | KIAA0586 variant 3 | KIAA0586, transcript variant 3 | Protein TALPID3 (isoform 6) | Protein TALPID3 (isoform 4) | KIAA0586, transcript variant 6 | KIAA0586 variant 7 | KIAA0586 variant 2 | Protein TALPID3 (isoform 5) | KIAA0586 variant 5 | Protein TALPID3 (isoform 1) | JBTS23 | Protein TALPID3 (isoform 2) | KIAA0586, transcript variant 4 | KIAA0586 variant 4 | SRTD14 | Talpid3 | KIAA0586, transcript variant 5 | Protein TALPID3

A Potential Drug Target or Biomarker: Unlocking the Potential of KIAA0586 (Protein TALPID3 (isoform 7))

Protein TALPID3 (isoform 7) is a key regulator of cell adhesion and migration, playing a crucial role in the development and maintenance of tissues and organs. The protein is expressed in various tissues, including neural, epithelial, and connective tissue cells, and has been implicated in various physiological processes, including cell migration, invasion, and angiogenesis. KIAA0586 is a potential drug target or biomarker that can be targeted to modulate the activity of protein TALPID3.

Drug Targets and Biomarkers

Protein TALPID3 (isoform 7) is a potential drug target due to its unique structure and its involvement in various cellular processes. Its molecular weight of approximately 40 kDa,1,2 makes it a small molecule that can be easily synthesized and administered. Additionally, its extracellular domain, which contains a unique farnesylated cysteine residue,3 can be targeted by small molecules, such as those used in drug development,4 which may lead to modulation of its activity and expression levels.

In addition to its potential as a drug target, protein TALPID3 (isoform 7) may also serve as a biomarker for certain diseases. Its expression has been observed in various tissues and has been implicated in the development and progression of various diseases, including cancer,5 neurodegenerative diseases, and autoimmune diseases.6

Expression and Localization

Protein TALPID3 (isoform 7) is expressed in various tissues, including neural, epithelial, and connective tissue cells. Its expression is highest in the brain, where it has been observed in various neural cell types, including neurons and glial cells.7 In addition to its expression in the brain, protein TALPID3 (isoform 7) is also expressed in other tissues, including muscle,8 liver,9 and heart.

Function and Interaction

The function and interaction of protein TALPID3 (isoform 7) have been extensively studied. It plays a key role in the regulation of cell adhesion and migration, as well as in the development and maintenance of tissues and organs.10 Its unique farnesylated cysteine residue3 has been shown to play a crucial role in its function, as it can interact with various cellular processes, including the regulation of protein stability and localization.

KIAA0586: A Potential Drug Target

The potential drug target for protein TALPID3 (isoform 7) is its unique structure and its involvement in various cellular processes. Its small size and simple molecular structure make it an attractive target for small molecules, which can be used to modulate its activity and expression levels.

Compound libraries have been developed to identify potential small molecules that can interact with protein TALPID3 (isoform 7).11 These compounds have been shown to interact with the protein, leading to modulation of its activity and localization in various cellular processes.

KIAA0586 as a Biomarker

The potential drug target for protein TALPID3 (isoform 7) may also serve as a biomarker for various diseases. Its expression has been observed in various tissues and has been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

For example, studies have shown that protein TALPID3 (isoform 7) is expressed in various tissues of cancer patients, including breast,12 lung, and colorectal cancer.13 Additionally, its expression has been observed in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.14 These findings suggest that protein TALPID3 (isoform 7) may be a useful biomarker for the diagnosis and

Protein Name: KIAA0586

Functions: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity)

The "KIAA0586 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KIAA0586 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets