JARID1D: A Promising Drug Target for Disabilities and Diseases

Target Name: KDM5D

NCBI ID: G8284

KDM5D

JARID1D: A Promising Drug Target for Disabilities and Diseases

Histone demethylase JARID1D is a protein that plays a crucial role in the regulation of gene expression and DNA methylation. Mutations in the JARID1D gene have been linked to a range of diseases, including cancer, neurodevelopmental disorders, and autoimmune diseases. As a result, JARID1D has emerged as a promising drug target for a variety of diseases.

The JARID1D gene is located on chromosome 16 and encodes a protein that belongs to the histone demethylase family. This family of proteins plays a critical role in the regulation of gene expression by modifying the level of histone modification on the DNA. Histone modification is a complex process that involves the addition of various chemical modifications to the histones, which are small proteins that make up the nucleosome. These modifications can include acetylation, methylation, and phosphorylation, and they play important roles in regulating gene expression.

JARID1D is a key enzyme in the JARID1D gene, and its function in the regulation of histone modification is well understood. JARID1D catalyzes the demethylation of the DNA by removing the methyl group from the cytosine residue on the 5' end of a CpG dinucleotide. This process is essential for the regulation of gene expression, as the level of histone modification on the DNA plays a critical role in the accessibility of gene promoters. Methylation of the promoter region of a gene can inhibit its transcription, while demethylation can increase accessibility and enhance gene expression.

JARID1D is also involved in the regulation of DNA methylation by removing the methyl group from the 5' end of a pre-methylated DNA fragment. This process is critical for the regulation of gene expression in the absence of a functional promoter. Methylation of the 5' end of a gene can inhibit its accessibility and reduce gene expression, while demethylation can increase accessibility and enhance gene expression.

In addition to its role in the regulation of histone modification and DNA methylation, JARID1D is also involved in the regulation of gene expression by modifying the level of histone modifications on the DNA. This process is known as histone dynamics, and it is critical for the regulation of gene expression by the histone enzymes.

JARID1D has been implicated in a variety of diseases, including cancer, neurodevelopmental disorders, and autoimmune diseases. For example, JARID1D mutations have been linked to the development of various cancers, including breast cancer, lung cancer, and colon cancer. In addition, JARID1D mutations have also been linked to the development of neurodevelopmental disorders, including Alzheimer's disease, Parkinson's disease, and Rett syndrome.

Given the importance of JARID1D in the regulation of gene expression and the role it plays in the regulation of histone modification and DNA methylation, it is a promising drug target for a variety of diseases. Researchers are currently working to develop small molecules that can inhibit the activity of JARID1D and enhance its function as a drug target. These small molecules include inhibitors of the JARID1D enzyme, as well as compounds that can modulate the activity of JARID1D to enhance its function as a drug target.

In conclusion, JARID1D is a protein that plays a critical role in the regulation of gene expression and DNA methylation. Its function in these processes is well understood, and JARID1D has been implicated in a variety of diseases. As a result, JARID1D is a promising drug target for a variety of diseases, including cancer, neurodevelopmental disorders, and autoimmune diseases. Further research is needed to develop small molecules that can inhibit the activity of JARID1D and enhance its function as a drug target.

Protein Name: Lysine Demethylase 5D

Functions: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks

The "KDM5D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KDM5D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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