KDM4A: Gene Involved in Gene Methylation and Multiple Biological Processes

Target Name: KDM4A

NCBI ID: G9682

KDM4A

KDM4A: Gene Involved in Gene Methylation and Multiple Biological Processes

KDM4A, also known as lysine (K)-specific demethylase 4A, is a gene that encodes a protein that is involved in the process of gene methylation. Methylation is a technique that involves the addition of a methyl group to specific DNA sequences. This process is important for the regulation of gene expression and has been implicated in a wide range of biological processes, including cell growth, development, and disease.

The KDM4A gene was first identified in 2008 and has since been shown to be involved in the regulation of gene expression in various organisms, including humans. The protein produced by this gene has been shown to have a variety of functions, including the regulation of cell cycle progression, the development of cancer, and the regulation of immune responses.

One of the key functions of KDM4A is its ability to demethylate the promoter region of a gene. Promoter regions are the regions of a gene that contain the information necessary to initiate gene expression. Demethylation of a promoter region would mean that the gene is not being transcribed into RNA, which would in turn reduce the level of protein produced by the gene.

KDM4A has been shown to play a key role in the regulation of gene expression in various biological processes. For example, studies have shown that KDM4A is involved in the regulation of cell cycle progression and the development of cancer. In cancer cells, KDM4A has been shown to be expressed at higher levels than in normal cells, and it has been implicated in the development of various types of cancer, including breast cancer and colon cancer.

In addition to its role in cancer development, KDM4A has also been shown to be involved in the regulation of immune responses. Studies have shown that KDM4A is involved in the regulation of T cell development and that it plays a key role in the regulation of inflammation.

KDM4A has also been shown to have a variety of potential drug targets. For example, studies have shown that KDM4A can be targeted with small molecules, including inhibitors, which could be used to treat a variety of diseases, including cancer and immune-related disorders.

In conclusion, KDM4A is a gene that encodes a protein that is involved in the process of gene methylation and has been shown to play a variety of roles in various biological processes. Its functions include the regulation of cell cycle progression, the development of cancer, and the regulation of immune responses. KDM4A has also been shown to have a variety of potential drug targets and could be used to treat a wide range of diseases. Further research is needed to fully understand the role of KDM4A in biology and to develop effective treatments for its various functions.

Protein Name: Lysine Demethylase 4A

Functions: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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