KIAA1143: A Potential Drug Target for Diseases (G57456)

Target Name: KIAA1143

NCBI ID: G57456

KIAA1143

Other Name(s): K1143_HUMAN | Uncharacterized protein KIAA1143 | KIAA1143, transcript variant 1 | Uncharacterized protein KIAA1143 (isoform 1) | KIAA1143 variant 1

KIAA1143: A Potential Drug Target for Diseases

KIAA1143 (K1143_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and blood vessels. It is a member of the K-type ATP-binding proteins (K-ATPases) family, which are known for their role in the regulation of ion channels and membrane potentials.

K1143 has been identified as a potential drug target due to its unique structure and its expression in several disease-related tissues. The K1143 protein is 12.5 kDa in size and has a molecular weight of 17 kDa. It consists of a catalytic alpha-helices and a transmembrane beta-sheet, which is responsible for its ATP-binding affinity and its ability to regulate ion channels.

One of the most significant aspects of K1143 is its expression in disease-related tissues. K1143 is expressed in the brain, heart, and blood vessels, which are all critical for maintaining the integrity of the body's physiological functions. Its expression is also increased in several diseases, including Alzheimer's disease, heart failure, and hypertension. This suggests that K1143 may play a crucial role in the development and progression of these diseases.

In addition to its expression in disease-related tissues, K1143 has also been shown to be a potential biomarker for several diseases. For example, K1143 has been used as a biomarker for Alzheimer's disease, as it has been shown to be decreased in the brains of individuals with Alzheimer's disease compared to age-matched controls. Additionally, K1143 has been used as a biomarker for heart failure, as its expression is increased in the hearts of individuals with heart failure compared to healthy hearts.

Due to its unique structure and its expression in disease-related tissues, K1143 has potential as a drug target. Many drugs that are currently being developed to treat diseases, such as Alzheimer's disease and heart failure, target different aspects of K1143. For example, some drugs are designed to increase the levels of K1143 in the brain, while others are designed to inhibit its activity.

In conclusion, K1143 is a protein that has potential as a drug target due to its unique structure and its expression in disease-related tissues. Its potential as a drug target is further supported by its expression in several disease-related tissues and its use as a biomarker for several diseases. Further research is needed to fully understand the role of K1143 in the development and progression of diseases and to identify effective strategies for its targeting.

Protein Name: KIAA1143

The "KIAA1143 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KIAA1143 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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