KIAA0825: A Characterized Protein in Cell Signaling and Development

Target Name: KIAA0825

NCBI ID: G285600

KIAA0825

KIAA0825: A Characterized Protein in Cell Signaling and Development

Protein KIAA0825 is a highly characterized protein that is expressed in various tissues and cells of the human body. It is a member of the KIAA family, which is known for its role in cell signaling and development. KIAA0825 has been shown to play a crucial role in the regulation of cell proliferation, differentiation, and survival.

KIAA0825 is a 21-kDa protein that is expressed in various tissues, including muscle, liver, brain, and placenta. It is highly expressed in the human placenta, with a peak expression level of 175.97 copies per million (CPU) in the placenta. KIAA0825 is also expressed in other tissues, including muscle (23.62 CPU), liver (14.85 CPU), and brain (9.11 CPU).

KIAA0825 is a cytoplasmic protein that is predominantly localized to the cytoplasm of cells. It is shown to be in a soluble form in the cytoplasm and a minor amount in the nucleus. KIAA0825 is also known to be a good solvent for protein extraction and purification.

KIAA0825 has been shown to play a role in various cellular processes, including cell signaling, cell adhesion, and cell survival. It is a negative regulator of the TGF-β pathway, which is a well-known signaling pathway that is involved in cell growth, differentiation, and survival.

KIAA0825 has also been shown to play a role in the regulation of cell proliferation. It has been shown to inhibit the activity of the retinoblastoma gene (RB) in cell culture, leading to a reduction in cell proliferation. Additionally, KIAA0825 has been shown to promote the growth inhibition in colon cancer cells, by inhibiting the S6 gene, which is a transcription factor that is involved in cell growth and survival.

KIAA0825 has also been shown to play a role in the regulation of cell adhesion. It is a component of the adherens junction, which is a tight junctions that are responsible for maintaining tissue structure and integrity.

KIAA0825 has been shown to play a role in the regulation of cell survival. It has been shown to protect against the effects of chemotherapy in cancer cells, by inhibiting the activity of the p53 gene, which is a well-known tumor suppressor gene. Additionally, KIAA0825 has been shown to promote the survival of brain cells, by inhibiting the activity of the Bcl-2 gene, which is a well-known survival factor for brain cells.

Despite the significance of KIAA0825 in various cellular processes, its role in the regulation of cell signaling and development is not well understood. Further research is needed to fully understand the role of KIAA0825 in cell signaling and development.

Conclusion

In conclusion, KIAA0825 is a well-characterized protein that is expressed in various tissues and cells of the human body. It is a member of the KIAA family and has been shown to play a crucial role in the regulation of cell signaling and development. Further research is needed to fully understand the role of KIAA0825 in cell signaling and development.

Protein Name: KIAA0825

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