Olfactory Receptor 4C3 as A Potential Drug Target for Alzheimer's and Parkinson's Diseases
Olfactory Receptor 4C3 as A Potential Drug Target for Alzheimer's and Parkinson's Diseases
Olfactory receptor 4C3 (OR4C3) is a protein that is expressed in the olfactory system, which is responsible for the sense of smell. OR4C3 is a G protein-coupled receptor (GPCR), which is a family of transmembrane proteins that play an important role in sensory perception.
The olfactory system is the only sense that the body has that is directly related to the brain. It is responsible for detecting scents and releasing signals to the brain that are responsible for creating the sensation of smell. The olfactory system is made up of several different proteins, including OR4C3.
OR4C3 is a 140 amino acid protein that is expressed in the olfactory system. It is located in the neurotransmitter vesicles, which is a structure that transports and delivers neurotransmitters, such as odorants, from the olfactory epithelium to the olfactory cortex.
OR4C3 is a GPCR, which means that it is a transmembrane protein that is composed of a protein tail and an intracellular domain. The protein tail is responsible for OR4C3's ability to interact with other proteins, while the intracellular domain is responsible for the functions that OR4C3 performs inside the cell.
OR4C3 is involved in the sense of smell because it is responsible for detecting and transmitting the signals from the olfactory neurons to the olfactory cortex. When a scent is detected, OR4C3 is activated and transmits the signal to the olfactory cortex, where the smell is processed and analyzed.
OR4C3 is a potential drug target because of its involvement in the sense of smell. Many diseases, such as Alzheimer's and Parkinson's, are characterized by the progressive loss of sensory abilities, including smell. Therefore, targeting OR4C3 with drugs that can preserve or restore sensory function may be a promising strategy for the development of new treatments for these diseases.
In addition to its involvement in the sense of smell, OR4C3 may also be a biomarker for some diseases. For example, people with Alzheimer's disease have been shown to have lower levels of OR4C3 in their olfactory system compared to healthy individuals. This suggests that OR4C3 may be a useful biomarker for the diagnosis and progression of Alzheimer's disease.
OR4C3 is also a potential target for drug development because of its unique structure and function. Unlike many other GPCRs, OR4C3 is not a classic GPCR, which means it does not have a well-characterized extracellular domain. This lack of information makes it difficult to predict the effects of potential drugs on OR4C3. However, this also allows for the possibility of novel compounds that can interact with OR4C3 in unique ways.
In conclusion, Olfactory receptor 4C3 (OR4C3) is a protein that is involved in the sense of smell and is a potential drug target due to its unique structure and function. The loss of OR4C3 in the olfactory system has been linked to the development of many diseases, including Alzheimer's and Parkinson's. Therefore, targeting OR4C3 with drugs that can preserve or restore sensory function may be a promising strategy for the development of new treatments for these diseases. Additionally, OR4C3 may also be a useful biomarker for the diagnosis and progression of these diseases. Further research is needed to fully understand the role of OR4C3 in the sense of smell and its potential as a drug target.
Protein Name: Olfactory Receptor Family 4 Subfamily C Member 3
Functions: Odorant receptor
The "OR4C3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR4C3 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15 | OR4K17 | OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1 | OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5 | OR4P4 | OR4Q3 | OR4S1 | OR4S2 | OR4T1P | OR4V1P | OR4X1 | OR4X2 | OR51A1P | OR51A2 | OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5 | OR52B2 | OR52B4 | OR52B6 | OR52D1 | OR52E1 | OR52E2 | OR52E4 | OR52E5 | OR52E6 | OR52E8 | OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1
