OR2B6: A GPCR Target for Cancer, Neurodegenerative Disorders and Psychiatric Conditions
OR2B6: A GPCR Target for Cancer, Neurodegenerative Disorders and Psychiatric Conditions
OR2B6 (OR2B6_HUMAN), a protein known as a G protein-coupled receptor (GPCR), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and psychiatric conditions. OR2B6 plays a crucial role in the regulation of various physiological processes in the body, including sensory perception, neurotransmitter signaling, and immune responses.
The OR2B6 gene, located on chromosome 7 (Xp21), encodes a 21-kDa protein that consists of an extracellular domain, a transmembrane segment, and an intracellular domain. The OR2B6 protein is expressed in various tissues and cells of the body, including the brain, sensory neurons, and immune cells.
OR2B6 functions as a GPCR, which is a type of transmembrane protein that uses intracellular signaling cascades to regulate various cellular processes. GPCRs are involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and hormone signaling. OR2B6 is specifically involved in the regulation of neurotransmitter signaling, which is critical for the function and behavior of neurons and neural tissue.
OR2B6 has been shown to play a role in the regulation of neurotransmitter signaling in various brain regions, including the prefrontal cortex, basal ganglia, and sensory cortices. OR2B6 has been shown to interact with several neurotransmitter receptors, including dopamine, serotonin, and GABA.
OR2B6 has also been shown to be involved in the regulation of pain perception and neuroinflammation. Pain perception is a complex physiological process that involves the regulation of pain modulation by various neurotransmitters and GPCRs. perception by modulating the activity of GABA receptors, which are involved in the inhibition of pain signaling.
In addition to its role in neurotransmitter signaling, OR2B6 has also been shown to be involved in the regulation of immune responses. OR2B6 has been shown to interact with the immune receptor PD-L1, which is involved in immune tolerance and regulation of inflammation.
OR2B6 has also been shown to be involved in the regulation of various psychiatric conditions, including depression and anxiety. OR2B6 has been shown to interact with the neurotransmitter receptor serotonin, which is involved in the regulation of mood and emotion.
Despite the potential clinical applications of OR2B6 as a drug target and biomarker, further research is needed to fully understand its function and the potential risks and benefits of targeting it. OR2B6 has been shown to be involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and immune responses, making it an attractive target for drug development. Further studies are needed to determine the efficacy and safety of targeting OR2B6 as a potential drug.
Protein Name: Olfactory Receptor Family 2 Subfamily B Member 6
Functions: Odorant receptor
The "OR2B6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR2B6 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
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