OR2Y1: A GPCR Molecule Responsible for Olfactory System and VOC Detection
OR2Y1: A GPCR Molecule Responsible for Olfactory System and VOC Detection
OR2Y1 (Olfactory receptor family 2 subfamily Y member 1) is a protein that is expressed in the olfactory system, which is responsible for the sense of smell. OR2Y1 is a G protein-coupled receptor (GPCR), which is a type of transmembrane protein that plays an important role in sensory perception. GPCRs are a family of proteins that are involved in a wide range of physiological processes in the body, including sensory perception, neurotransmitter signaling, and cell signaling.
The Olfactory system is one of the most complex sensory systems in the body. It is responsible for the sense of smell, which is closely linked to the brain's reward system. The olfactory system is made up of a complex network of neurons and specialized cells that are responsible for detecting and processing sensory information. One of the key proteins that is involved in this system is OR2Y1.
OR2Y1 is a GPCR that is expressed in the olfactory system, specifically in the epithelial cells that line the nasal cavity. It is a 120-amino acid protein with a calculated pI of 1.85. OR2Y1 is involved in the detection and perception of volatile organic compounds (VOCs), which are chemicals that are responsible for the smell of food, beverages, and other scents.
OR2Y1 is a member of the Olfactory receptor family 2, which is a subfamily of GPCRs that are involved in sensory perception. The Olfactory receptor family 2 consists of four subunits: OR2Y1, OR2Y2, OR2Y3, and OR2Y4. These subunits are involved in the detection and perception of different types of VOCs, including sweet, sour, and bitter tastes.
OR2Y1 is specifically involved in the detection and perception of butyric acid, which is a strong smelling VOC that is responsible for the taste and smell of butter. When butyric acid is introduced to the olfactory system, it triggers a signaling cascade that results in the release of nitric oxide (NO) from specialized cells in the olfactory system. This increase in NO is then used by the cells to create a sense of smell.
OR2Y1 is also involved in the regulation of the activity of other GPCRs in the olfactory system. For example, it has been shown to regulate the activity of the GPCR known as OR101, which is involved in the perception of sweet and sour tastes. OR2Y1 has also been shown to interact with the GPCR known as OR71, which is involved in the perception of ammonia and other strong VOCs.
OR2Y1 is a potential drug target in the field of sensory perception. Its involvement in the detection and perception of butyric acid makes it an attractive target for compounds that are designed to enhance or block the perception of this VOC. Additionally, its role in the regulation of the activity of other GPCRs in the olfactory system makes it a potential target for drugs that are designed to modulate the activity of these receptors.
In conclusion, OR2Y1 is a protein that is involved in the olfactory system and is responsible for the detection and perception of VOCs. Its role in this system is highly relevant to the sense of smell, which is closely linked to the brain's reward system. As a result, OR2Y1 is an attractive target for drugs that are designed to enhance or block the perception of VOCs. Additionally, its role in the regulation of the activity of other GPCRs in the olfactory system makes it a potential target for drugs that are designed to modulate the activity of these receptors. Further research is needed to fully understand the role of OR2Y1 in
Protein Name: Olfactory Receptor Family 2 Subfamily Y Member 1
Functions: Odorant receptor
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OR2Z1 | OR3A1 | OR3A2 | OR3A3 | OR3A4P | OR4A14P | OR4A15 | OR4A16 | OR4A17P | OR4A21P | OR4A47 | OR4A5 | OR4B1 | OR4C11 | OR4C12 | OR4C13 | OR4C15 | OR4C16 | OR4C1P | OR4C3 | OR4C45 | OR4C46 | OR4C5 | OR4C50P | OR4C6 | OR4D1 | OR4D10 | OR4D11 | OR4D2 | OR4D5 | OR4D6 | OR4D9 | OR4E2 | OR4F13P | OR4F15 | OR4F16 | OR4F17 | OR4F21 | OR4F29 | OR4F3 | OR4F4 | OR4F5 | OR4F6 | OR4G3P | OR4K1 | OR4K13 | OR4K14 | OR4K15 | OR4K17 | OR4K2 | OR4K5 | OR4K6P | OR4K7P | OR4L1 | OR4M1 | OR4M2 | OR4M2-OT1 | OR4N2 | OR4N3P | OR4N4 | OR4N5 | OR4P4 | OR4Q3 | OR4S1 | OR4S2 | OR4T1P | OR4V1P | OR4X1 | OR4X2 | OR51A1P | OR51A2 | OR51A3P | OR51A4 | OR51A6P | OR51A7 | OR51B2 | OR51B4 | OR51B5 | OR51B6 | OR51C1P | OR51D1 | OR51E1 | OR51E2 | OR51F1 | OR51F2 | OR51G1 | OR51G2 | OR51H1 | OR51I1 | OR51I2 | OR51J1 | OR51L1 | OR51M1 | OR51Q1 | OR51S1 | OR51T1 | OR51V1 | OR52A1 | OR52A4P | OR52A5
