Target Name: GGT1
NCBI ID: G2678
Review Report on GGT1 Target / Biomarker Content of Review Report on GGT1 Target / Biomarker
GGT1
Other Name(s): GGT | Glutathione hydrolase 1 | Gamma-glutamyltranspeptidase 1 heavy chain | CD224 | Gamma-glutamyltranspeptidase 1 light chain | Gamma-glutamyltransferase 1 | gamma-glutamyltranspeptidase 1 | D22S672 | GGT 1 | Gamma-Glutamyltranspeptidase 1 | Glutathione hydrolase 1 proenzyme | GGT1 variant 6 | gamma-Glutamyltransferase 1, transcript variant 6 | Glutathione hydrolase 1 light chain | testicular tissue protein Li 73 | leukotriene-C4 hydrolase | GTG | Leukotriene-C4 hydrolase | gamma-glutamyltransferase 1 | Glutathione hydrolase 1 heavy chain | D22S732 | GGT1_HUMAN | GGTD

GGT1: Key Component of The Neuroendocrine System

GGT1 (Gastrin-Oddi secretion) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a key component of the neuroendocrine system and has been implicated in a number of physiological processes, including the regulation of appetite and metabolism.

GGT1 is a transmembrane protein that is expressed in the epithelial cells of the intestine, pancreas, and other tissues. It is composed of two main chains, an N-terminal chain that contains the catalytic active site and a C-terminal chain that contains a number of potential interacting proteins. The N-terminal chain consists of a catalytic domain that is responsible for the protein's catalytic activity, as well as a number of putative transmembrane domains that are involved in the protein's stability and interactions with other molecules. The C-terminal chain includes a number of potential interacting proteins, including a number of serine/thr protein kinases, as well as a number of potential interacting proteins that are involved in the regulation of various cellular processes, including cell signaling and metabolism.

GGT1 is involved in the regulation of a number of physiological processes that are critical for the survival and proper functioning of the body. For example, it is involved in the regulation of appetite and metabolism, as well as the regulation of the production of hormones that are involved in these processes. It is also involved in the regulation of the growth and development of tissues, as well as the regulation of cell signaling and metabolism.

In addition to its involvement in the regulation of appetite and metabolism, GGT1 is also thought to be involved in the regulation of a number of other physiological processes that are critical for the survival and proper functioning of the body. For example, it is involved in the regulation of thirst and the regulation of the production of water in the body. It is also involved in the regulation of the production of insulin in the pancreas, as well as the regulation of the production of other hormones that are involved in these processes.

GGT1 is also thought to be involved in the regulation of the development and progression of various diseases, including cancer. For example, it is has been shown to be involved in the regulation of the development of pancreatic cancer, and it is also thought to be involved in the regulation of the development of other cancers, including breast, lung, and ovarian cancer.

GGT1 is also a potential drug target and has been shown to be involved in a number of signaling pathways that are involved in the development and progression of various diseases. For example, it is thought to be involved in the regulation of the production of pro-inflammatory cytokines, which are involved in the development of cancer and other diseases. It is also thought to be involved in the regulation of the production of anti-inflammatory cytokines, which are involved in the regulation of inflammation and other processes that are important for the immune system.

In conclusion, GGT1 is a protein that is involved in a number of physiological processes that are critical for the survival and proper functioning of the body. It is a key component of the neuroendocrine system and is involved in the regulation of a wide range of physiological processes, including appetite and metabolism, the production of hormones, and the regulation of the development and progression of diseases. As a result, GGT1 is a potential drug target and has been shown to be involved in a number of signaling pathways that are involved in the development and progression of various diseases. Further research is needed to fully understand the role of GGT1 in these processes and to develop effective treatments for the prevention and treatment of these diseases.

Protein Name: Gamma-glutamyltransferase 1

Functions: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:17924658, PubMed:21447318, PubMed:27791009). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases (PubMed:27791009). In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:17924658, PubMed:7673200, PubMed:7759490, PubMed:8095045, PubMed:8827453, PubMed:21447318). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4

The "GGT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GGT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

GGT2P | GGT3P | GGT5 | GGT6 | GGT7 | GGT8P | GGTA1 | GGTLC1 | GGTLC2 | GGTLC3 | GH1 | GH2 | GHDC | GHITM | GHR | GHRH | GHRHR | GHRL | GHRLOS | GHSR | GID4 | GID8 | GIGYF1 | GIGYF2 | GIHCG | GIMAP1 | GIMAP1-GIMAP5 | GIMAP2 | GIMAP3P | GIMAP4 | GIMAP5 | GIMAP6 | GIMAP7 | GIMAP8 | GIMD1 | GIN1 | GINM1 | GINS complex | GINS1 | GINS2 | GINS3 | GINS4 | GIP | GIPC1 | GIPC2 | GIPC3 | GIPR | GIT1 | GIT2 | GJA1 | GJA10 | GJA1P1 | GJA3 | GJA4 | GJA5 | GJA8 | GJA9 | GJA9-MYCBP | GJB1 | GJB2 | GJB3 | GJB4 | GJB5 | GJB6 | GJB7 | GJC1 | GJC2 | GJC3 | GJD2 | GJD3 | GJD4 | GK | GK2 | GK3 | GK5 | GKAP1 | GKN1 | GKN2 | GKN3P | GLA | GLB1 | GLB1L | GLB1L2 | GLB1L3 | GLC1C | GLCCI1 | GLCCI1-DT | GLCE | GLDC | GLDN | GLE1 | GLG1 | GLI1 | GLI2 | GLI3 | GLI4 | GLIDR | GLIPR1 | GLIPR1L1 | GLIPR1L2