Target Name: GHITM
NCBI ID: G27069
Review Report on GHITM Target / Biomarker Content of Review Report on GHITM Target / Biomarker
GHITM
Other Name(s): transmembrane BAX inhibitor motif containing 5 | FLJ26584 | mitochondrial morphology and cristae structure 1 | growth hormone inducible transmembrane protein | GHITM_HUMAN | TMBIM5 | Transmembrane BAX inhibitor motif-containing protein 5 | PTD010 | Transmembrane BAX inhibitor motif containing 5 | DERP2 | My021 | HSPC282 | MICS1 | dermal papilla-derived protein 2 | Growth hormone-inducible transmembrane protein | Dermal papilla-derived protein 2 | transmembrane BAX inhibitor motif-containing protein 5 | DKFZp566C0746 | Mitochondrial morphology and cristae structure 1 | Growth hormone inducible transmembrane protein

GHITM-BAX: A Unique Protein with Potential as A Drug Target and Biomarker

GHITM (GHITM-BAX) is a unique protein that is found in various cell types, including neurons and endothelial cells. It is characterized by its transmembrane structure and the presence of a specific motif that is composed of five basic amino acids: alanine, glutamic acid, isoleucine, lysine, and methionine.

The GHITM-BAX motif is highly conserved across various species, which suggests that it may be an important protein that plays a critical role in the function of many different cell types. Additionally, the GHITM-BAX protein has been shown to play a role in several cellular processes, including cell signaling, cell adhesion, and cell survival.

One of the most promising aspects of GHITM-BAX is its potential as a drug target. TheGHITM-BAX protein has been shown to interact with several different signaling pathways, including the TGF-β pathway and the PI3K/Akt pathway. These interactions suggest that GHITM-BAX may be a useful target for the development of new pharmaceuticals that can modulate these signaling pathways.

In addition to its potential as a drug target, GHITM-BAX is also a potential biomarker for several diseases. For example,GHITM-BAX has been shown to be downregulated in several types of cancer, including breast, ovarian, and prostate cancer. This suggests that GHITM-BAX may be a useful biomarker for the early detection and treatment of these diseases.

Another promising aspect of GHITM-BAX is its role in cell signaling. GHITM-BAX has been shown to play a role in several signaling pathways, including the TGF-β pathway and the PI3K/Akt pathway. These interactions suggest that GHITM-BAX may be a useful target for the development of new drugs that can modulate these signaling pathways.

GHITM-BAX has also been shown to play a role in several cellular processes, including cell adhesion and cell survival. For example, GHITM-BAX has been shown to be involved in the regulation of cell adhesion, which is important for the proper functioning of tissues and organs. Additionally, GHITM-BAX has been shown to play a role in the regulation of cell survival, which is important for the proper functioning of tissues and organs.

In conclusion, GHITM-BAX is a unique protein that is characterized by its transmembrane structure and the presence of a specific motif composed of five basic amino acids. The GHITM-BAX protein has been shown to play a role in several cellular processes, including cell signaling, cell adhesion, and cell survival. Its potential as a drug target and biomarker make it an attractive target for the development of new pharmaceuticals and diagnostic tools.

Protein Name: Growth Hormone Inducible Transmembrane Protein

Functions: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18417609, PubMed:36321428, PubMed:32977469, PubMed:35912435). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:36321428, PubMed:35912435). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:36321428). Required for the mitochondrial tubular network and cristae organization (PubMed:18417609, PubMed:36321428, PubMed:32977469). Involved in apoptotic release of cytochrome c (PubMed:18417609). Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (PubMed:36321428). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (PubMed:36321428)

The "GHITM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GHITM comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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