Target Name: GIGYF2
NCBI ID: G26058
Review Report on GIGYF2 Target / Biomarker Content of Review Report on GIGYF2 Target / Biomarker
GIGYF2
Other Name(s): PERQ3 | GRB10-interacting GYF protein 2 (isoform a) | GRB10 interacting GYF protein 2, transcript variant 3 | GIGYF2 variant 3 | DKFZp686I15154 | FLJ23368 | GYF2 | PERQ amino acid-rich with GYF domain-containing protein 2 | GGYF2_HUMAN | GRB10-interacting GYF protein 2 (isoform b) | GIGYF2 variant 4 | PERQ amino acid rich, with GYF domain 2 | Trinucleotide repeat containing 15 | GRB10 interacting GYF protein 2, transcript variant 1 | Parkinson disease (autosomal recessive, early onset) 11 | TNRC15 | trinucleotide repeat-containing gene 15 protein | GRB10-interacting GYF protein 2 (isoform c) | PARK11 | GRB10-interacting GYF protein 2 | GIGYF2 variant 1 | GYF domain containing 2 | GRB10 interacting GYF protein 2 | PERQ2 | DKFZp686J17223 | GRB10 interacting GYF protein 2, transcript variant 2 | GIGYF2 variant 2 | GRB10 interacting GYF protein 2, transcript variant 4 | Trinucleotide repeat-containing gene 15 protein | PERQ amino acid rich, with GYF domain 3 | KIAA0642

GIGYF2: A Protein Involved in Various Physiological Processes and Potential Drug Targets

GIGYF2 (Perq3) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling.

GIGYF2 is involved in a wide range of physiological processes in the body, including modulating neurotransmitter signaling, regulating inflammation, and contributing to tissue repair and regeneration. Its function is supported by a growing body of research, which has identified it as a potential drug target and biomarker for a variety of diseases.

One of the key functions of GIGYF2 is its role in modulating neurotransmitter signaling. GIGYF2 is a critical receptor for the neurotransmitter GABA, which is involved in a wide range of brain functions, including mood regulation, learning, and memory. GABA is known for its ability to inhibit the activity of other neurons, which is important for the normal functioning of the brain.

In addition to its role in modulating neurotransmitter signaling, GIGYF2 is also involved in regulating inflammation. GIGYF2 has been shown to play a key role in the regulation of inflammation in various tissues, including the brain. Its function in this context is thought to be related to its ability to modulate the activity of immune cells and regulate the production of pro-inflammatory cytokines.

GIGYF2 is also involved in tissue repair and regeneration. Its role in this context is supported by research in the field of neurodegenerative diseases, where GIGYF2 has been shown to contribute to the pathology of conditions such as Alzheimer's disease and Parkinson's disease.

GIGYF2 has also been identified as a potential biomarker for a variety of diseases. Its expression has been shown to be altered in a wide range of diseases, including neurodegenerative diseases, cancer, and autoimmune disorders. This suggests that GIGYF2 may be a useful diagnostic or therapeutic target in these conditions.

In conclusion, GIGYF2 is a protein that is involved in a wide range of physiological processes in the body. Its function is supported by a growing body of research, which has identified it as a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of GIGYF2 in these processes and to develop effective treatments for the various conditions that it is involved in.

Protein Name: GRB10 Interacting GYF Protein 2

Functions: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153)

The "GIGYF2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GIGYF2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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