Target Name: GIMAP5
NCBI ID: G55340
Review Report on GIMAP5 Target / Biomarker Content of Review Report on GIMAP5 Target / Biomarker
GIMAP5
Other Name(s): immune associated nucleotide 4 like 1 | Immunity associated protein 3 | inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5 | GTPase, IMAP family member 5 | Immunity-associated nucleotide 5 protein | NCPH2 | IROD | hIAN5 | immune-associated nucleotide-binding protein 5 | HIMAP3 | IAN5 | IAN-5 | IAN4 | GTPase IMAP family member 5 | Immunity-associated nucleotide 4-like 1 protein | Immune associated nucleotide 4 like 1 (mouse) | Immune-associated nucleotide-binding protein 5 | IAN4L1 | IMAP3 | immunity-associated nucleotide 5 protein | immunity associated protein 3 | Immunity-associated protein 3 | GIMA5_HUMAN

Understanding GIMAP5: A Potential Drug Target in Immunology

GIMAP5 (Immune Associated Nucleotide 4-Like 1) is a protein that is expressed in various tissues of the body, including the blood cells, tissues, and organs. It is a small non-coding RNA molecule that plays a crucial role in the immune response. GIMAP5 is associated with the regulation of immune cell function and has been identified as a potential drug target in the field of immunology.

GIMAP5 is a key regulator of the T cell response. It is known to be involved in the regulation of T cell development, activation, and proliferation. GIMAP5 has been shown to play a role in the regulation of CD4+ and CD8+ T cell responses, as well as natural killer cell function.

In addition to its role in T cell regulation, GIMAP5 is also involved in the regulation of immune cell survival. Studies have shown that GIMAP5 can promote the survival of immune cells, such as natural killer cells, by regulating the production of cell cycle inhibitors.

GIMAP5 is also associated with the regulation of inflammation. It has been shown to play a role in the regulation of inflammation-related processes, including the production of pro-inflammatory cytokines.

GIMAP5 has also been shown to be involved in the regulation of cell signaling pathways. It has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, a pathway that is involved in the regulation of cell signaling and survival.

GIMAP5 is also associated with the regulation of gene expression. Studies have shown that GIMAP5 can regulate the expression of various genes, including genes involved in cell signaling, DNA replication, and apoptosis.

GIMAP5 has been shown to be involved in the regulation of cellular processes that are important for immune cell function, including T cell development, activation, and proliferation. It is therefore a potential drug target in the field of immunology.

GIMAP5 is also of interest as a biomarker for certain diseases. For example, GIMAP5 has been shown to be decreased in individuals with certain types of cancer, such as lung cancer. This suggests that GIMAP5 may be a useful biomarker for the diagnosis and treatment of certain types of cancer.

In conclusion, GIMAP5 is a protein that is involved in the regulation of various cellular processes that are important for immune cell function. Its role in T cell regulation, immune cell survival, inflammation, and cellular signaling pathways makes it a potential drug target in the field of immunology. Further research is needed to fully understand the role of GIMAP5 in human health and disease.

Protein Name: GTPase, IMAP Family Member 5

Functions: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed:29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity)

The "GIMAP5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GIMAP5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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