TRUB2: A Potential Drug Target and Biomarker (G26995)

Target Name: TRUB2

NCBI ID: G26995

TRUB2

TRUB2: A Potential Drug Target and Biomarker

TRUB2, a protein found in various tissues of the brain, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. Its function in the brain and its involvement in several neurotransmitter systems make it an attractive target for drug development.

TRUB2 is a key regulator of the neurotransmitter acetylcholine, which is involved in memory, attention, and neural communication. It is a transmembrane protein that is expressed in different tissues of the brain, including the prefrontal cortex, basal ganglia, and cerebellum. Its function is to regulate the levels of acetylcholine in the brain, which is crucial for the normal functioning of neurons.

Research has shown that TRUB2 is involved in the regulation of several neurotransmitter systems, including dopamine, serotonin, and GABA. It has been shown to play a role in the development of several psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.

One of the key reasons for TRUB2's potential as a drug target is its involvement in the regulation of neurotransmitter systems. Many psychiatric disorders are characterized by the imbalance of neurotransmitters in the brain, which can lead to the development of symptoms such as anxiety, depression, and psychosis. By targeting TRUB2, drugs can potentially normalize the levels of neurotransmitters in the brain and improve mood, cognitive function, and overall quality of life.

Another reason for TRUB2's potential as a drug target is its involvement in several neurotransmitter systems. TRUB2 has been shown to regulate the levels of dopamine, a neurotransmitter that is involved in motor control and mood regulation. Studies have shown that TRUB2 plays a role in the regulation of dopamine levels in the brain and that its dysfunction can contribute to the development of Parkinson's disease.

In addition to its role in neurotransmitter regulation, TRUB2 has also been shown to play a role in the development of certain psychiatric disorders. Studies have shown that TRUB2 is involved in the regulation of serotonin levels in the brain and that its dysfunction can contribute to the development of depression.

TRUB2 has also been shown to play a role in the regulation of GABA, a neurotransmitter that is involved in the regulation of anxiety and depression. Studies have shown that TRUB2 is involved in the regulation of GABA levels in the brain and that its dysfunction can contribute to the development of anxiety.

Despite its potential as a drug target, TRUB2 is still an relatively unstudied protein. There are only a few studies that have investigated its function in the brain and its potential as a drug target. Further research is needed to fully understand its role in neurotransmitter regulation and its potential as a drug target.

In conclusion, TRUB2 is a protein that has been identified as a potential drug target and biomarker for several neurological and psychiatric disorders. Its function in the neurotransmitter regulation makes it an attractive target for drug development. Further research is needed to fully understand its role in the brain and its potential as a drug target.

Protein Name: TruB Pseudouridine Synthase Family Member 2

Functions: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933)

The "TRUB2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRUB2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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