EIF-3p28: A Potential Drug Target and Biomarker (G27335)

Target Name: EIF3K

NCBI ID: G27335

EIF3K

EIF-3p28: A Potential Drug Target and Biomarker

Introduction

EIF-3p28 is a protein that is expressed in various tissues, including the brain, heart, and pancreas. It is a key regulator of the unfolded state of proteins, which is a critical stage in their life cycle. Discovered in 2004, EIF- 3p28 has since been shown to play a crucial role in a variety of physiological processes, including cell survival, metabolism, and inflammation. In this article, we will explore the potential implications of EIF-3p28 as a drug target and biomarker.

The Importance of EIF-3p28

EIF-3p28 is a 28-kDa protein that is composed of two main subunits, EIF-3 and EIF-4. The EIF-3 subunit consists of a 166 amino acid protein that contains a unique N-terminal domain, known as the N -Terminal alpha helix. This domain is critical for the stability and localization of the protein to the endoplasmic reticulum (ER), where it can be involved in various cellular processes.

The EIF-3p28 protein is involved in the regulation of protein folding by promoting the formation of the unfolded state. In the ER, proteins are translated from mRNA and then processed to create a specific conformational state. However, only a small percentage of these proteins can successfully transition from the ER to the cytosol, where they can be involved in various cellular processes. EIF-3p28 plays a crucial role in this process by helping to establish the unfolded state of proteins.

In addition to its role in protein folding, EIF-3p28 has also been shown to be involved in various cellular processes that are critical for cell survival. For example, EIF-3p28 has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells commit suicide to avoid being damaged or no longer needed. In addition, EIF-3p28 has also been shown to play a role in the regulation of cell metabolism, including the regulation of energy metabolism and the metabolism of nutrients.

Potential as a Drug Target

The potential use of EIF-3p28 as a drug target is due to its involvement in various cellular processes that are critical for cell survival. EIF-3p28 has been shown to play a role in the regulation of cell apoptosis, which is a critical process for the control of cell numbers and the regulation of tissue homeostasis. In addition, EIF-3p28 has also been shown to play a role in the regulation of cell metabolism, including the regulation of energy metabolism and the metabolism of nutrients.

One potential approach to targeting EIF-3p28 is to use small molecules that can modulate its activity. These small molecules can either activate or inhibit the activity of EIF-3p28, depending on its state in the cell. EIF-3p28 is to use small molecules that can inhibit its activity in the ER, where it is involved in the regulation of protein folding.

Another potential approach to targeting EIF-3p28 is to use small molecules that can modulate its activity in the cytosol, where it is involved in various cellular processes. For example, one potential approach to targeting EIF-3p28 is to use small molecules that can inhibit its activity in the cytosol, where it is involved in the regulation of cell apoptosis and cell metabolism.

Biomarker Potential

In addition to its potential as a drug target, EIF-3p28 also has potential as a biomarker. The regulation of protein folding is a critical process that is involved in

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit K

Functions: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)

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