CEP63: A Protein Involved in Cell Division, Cell Cycle, Apoptosis and Cell Migration

Target Name: CEP63

NCBI ID: G80254

CEP63

CEP63: A Protein Involved in Cell Division, Cell Cycle, Apoptosis and Cell Migration

Centrosomal protein 63 (CEP63) is a protein that is expressed in various cell types, including neurons and cancer cells. It is a member of the centrosome complex, which is a protein structure that is found in the center of each cell nucleus. The centrosome complex is involved in the proper functioning of cell division and is a key regulator of the cell cycle.

CEP63 is a transmembrane protein, which means that it spans the cell membrane and extends into the cytoplasm. It is made up of four distinct subunits, which are held together by non-covalent interactions. The subunits of CEP63 include a N-terminal alpha helix , a B-terminal alpha-helices, a C-terminal alpha-helix, and a D-terminal beta-sheet.

CEP63 is involved in the regulation of cell division and cell cycle progression. It plays a key role in the establishment and maintenance of the microtubules, which are the protein structures that make up the cytoskeleton. Microtubules provide structural support to the cell and help to regulate the movement of cells within the body.

CEP63 is also involved in the regulation of the actin filaments. Actin filaments are a type of protein structure that are found in the cytoskeleton and help to regulate the movement of cells. CEP63 helps to regulate the stability of the actin filaments and is thought to play a key role in the regulation of cell movement.

CEP63 is also involved in the regulation of the centrosome. The centrosome is an important organelle in cells that participates in cell division and cell cycle processes. CEP63 plays a critical role in centrosome function and stability.

In addition, CEP63 is associated with many important biological processes. For example, it is associated with apoptosis, an important form of cell death. During apoptosis, CEP63 can help maintain intracellular homeostasis and ensure that intracellular degradation processes are properly controlled.

In addition, CEP63 is also associated with cell migration. Cell migration is the process by which cells spread within solid tissues and is critical for tissue regeneration and repair. The function of CEP63 is related to cell migration, and research suggests that it may be a potential drug target.

In addition, CEP63 is also associated with neuronal survival and apoptosis. Neurons are the basic units of the nervous system, and CEP63 plays a key role in the survival and apoptosis of neurons. Studies have shown that dysfunction of CEP63 is closely related to the pathogenesis of neuronal diseases.

CEP63 is an important protein that participates in many important biological processes. It is a potential drug target and is important for studying cell division, cell cycle processes, apoptosis, cell migration, and neuronal diseases.

The biological functions of CEP63 and its role in biological processes make it a very attractive research object. In the future, researchers will continue to study the function and mechanism of CEP63 in depth to better understand its importance and role.

Protein Name: Centrosomal Protein 63

Functions: Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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