CEP78: A Cancer-Promoting Protein and A Potential Drug Target

Target Name: CEP78

NCBI ID: G84131

CEP78

CEP78: A Cancer-Promoting Protein and A Potential Drug Target

Centrosomal protein 78 (CEP78) is a protein that is found in the centrosome, which is a complex of DNA, RNA, and proteins that is responsible for organizing and regulating cell division. CEP78 is a key component of the centrosome and plays a crucial role in the regulation of cell division and the development of cancer.

Recent studies have identified CEP78 as a potential drug target and biomarker for a variety of diseases, including cancer. CEP78 has been shown to be highly expressed in a variety of cancer types, including breast, ovarian, and colorectal cancers. Additionally, studies have shown that inhibiting CEP78 can lead to a variety of cellular and molecular changes that can promote cancer growth.

One of the key mechanisms by which CEP78 promotes cancer growth is its role in the regulation of the cytoskeleton. The cytoskeleton is the structure that gives cells shape and stability, and it is critical for the proper functioning of cells. CEP78 is involved in the regulation of the cytoskeleton by helping to control the movement of cells and the formation of tight junctions between cells. When these processes are disrupted, as is often the case in cancer, cells can begin to behave abnormally and can eventually develop into tumors.

Another mechanism by which CEP78 promotes cancer growth is its role in cell adhesion. CEP78 helps to hold cells together and is involved in the formation of tight junctions between cells. When cells are attached to each other, they are able to communicate with each other and work together to support the growth and development of tissues. In cancer, these processes can be disrupted, leading to the development of tumors.

In addition to its role in cell division and adhesion, CEP78 has also been shown to play a role in the regulation of cell signaling pathways. For example, studies have shown that CEP78 can interact with the protein known as p53, which is a key regulator of DNA damage repair. When p53 is activated, it can cause CEP78 to become phosphorylated, which can then trigger a variety of cellular responses.

Given the potential role of CEP78 in the regulation of cell division, signaling pathways, and the cytoskeleton, researchers are actively seeking new ways to target this protein in the treatment of cancer. One approach is to develop drugs that specifically inhibit CEP78, either by blocking its synthesis or by inhibiting its function. This approach is still in the early stages of development, but it holds great promise as a new treatment for a variety of cancer types.

Another approach is to use CEP78 as a biomarker to predict the outcome of cancer treatment. By measuring the levels of CEP78 in cancer cells before and after treatment, researchers can gain insights into the effectiveness of different treatments and identify potential biomarkers for cancer. This approach has the potential to revolutionize cancer treatment by allowing doctors to tailor treatments to individual patients based on their unique genetic profiles.

In conclusion, CEP78 is a protein that plays a crucial role in the regulation of cell division and the development of cancer. Its role in these processes makes it an attractive target for drug development, and its potential as a biomarker for cancer treatment adds to its importance. As research continues to advance, it is likely that we will learn even more about the mechanisms by which CEP78 promotes cancer growth and the potential of this protein as a new treatment for a variety of diseases.

Protein Name: Centrosomal Protein 78

Functions: May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451)

The "CEP78 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CEP78 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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