AQP11: A Promising Drug Target and Biomarker for the treatment of water conservancy diseases

Target Name: AQP11

NCBI ID: G282679

AQP11

AQP11: A Promising Drug Target and Biomarker for the treatment of water conservancy diseases

Introduction

Aquaporin 11 (AQP11) is a water channel protein that plays a crucial role in regulation of water and salt balance in the human body. It is a member of the AQP family, which includes ten transmembrane proteins that are involved in water transport and regulation. The primary function of AQP11 is to promote water intake and promote water excretion in the urine, which is essential for maintaining the proper hydration balance in the body. However, AQP11 has also been implicated in several diseases, including obesity, diabetes, and cardiovascular disease . As a result, it is a drug target of great interest and a potential biomarker for several diseases.

Diseases associated with AQP11

AQP11 is involved in several diseases, including obesity, diabetes, and cardiovascular disease. Obesity is a major public health issue that is associated with several diseases, including diabetes, cardiovascular disease, and certain cancers. It is estimated that the global obesity population will reach 9.69 billion by 2050, with a prevalence of 28.5% for adults and 5.5% for children. The increased body weight is associated with an increased risk of developing several diseases, including AQP11-related diseases.

AQP11 and obesity

Obesity is associated with an increased risk of developing AQP11-related diseases, including the development of insulin resistance, which is a risk factor for type 2 diabetes. Insulin resistance is a condition in which the body's cells become less responsive to insulin, making it difficult for the body to use insulin to lower blood sugar levels. This condition is associated with an increased risk of developing type 2 diabetes, which is a major cause of morbidity and mortality.

AQP11 and diabetes

AQP11 is also involved in the regulation of blood sugar levels. It has been shown to play a role in insulin sensitivity, which is the ability of the body's cells to respond to insulin. Insulin sensitivity is an important factor in the development of type 2 diabetes , as individuals with type 2 diabetes have reduced insulin sensitivity. Several studies have shown that individuals with obesity are less insulin sensitive than individuals with normal weight. This reduced insulin sensitivity is associated with an increased risk of developing type 2 diabetes.

AQP11 and cardiovascular disease

AQP11 is also involved in the regulation of blood pressure, which is an important factor in the development of cardiovascular disease. High blood pressure, or hypertension, is associated with an increased risk of developing cardiovascular disease, including heart attack, stroke, and heart failure . Several studies have shown that individuals with obesity have an increased risk of developing hypertension, which is a risk factor for cardiovascular disease.

Drug targets for AQP11

AQP11 is a drug target of great interest due to its involvement in several diseases. Researchers have identified several potential drug targets for AQP11, including inhibition of AQP11 function, which may be an effective way to treat obesity, diabetes, and cardiovascular disease.

In conclusion

AQP11 is a water channel protein that is involved in regulation of water and salt balance in the human body. It is a member of the AQP family and has been implicated in several diseases, including obesity, diabetes, and cardiovascular disease. As a result, AQP11 is a drug target of great interest and a potential biomarker for several diseases. Further research is needed to fully understand the role of AQP11 in disease and to develop effective treatments.

Protein Name: Aquaporin 11

Functions: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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