TRBV12-3: A Potential Drug Target and Biomarker for T Cell Receptor尾 Variable 12-3

Target Name: TRBV12-3

NCBI ID: G28577

TRBV12-3

Other Name(s): T cell receptor beta variable 12-3 | TCRBV12S3 | TRBV123 | TCRBV8S1

TRBV12-3: A Potential Drug Target and Biomarker for T Cell Receptor尾 Variable 12-3

T cells are a crucial part of the immune system, and their role is to detect and respond to foreign antigens in the body. T cell receptor beta variable 12-3 (TRBV12-3) is a protein that plays a critical role in this process. TRBV12-3 is a type of protein known as a tyrosine kinase, which means it attaches to other proteins using a protein called a tyrosine. These tyrosine-protein interactions can modulate the activity of TRBV12-3, and potentially serve as drug targets or biomarkers.

TRBV12-3 is a protein that is expressed in many different tissues throughout the body, including the skin, hair, and nails. It is also highly expressed in the testes, which suggests that it may be involved in sexual function. TRBV12-3 is a 21-kDa protein that is composed of two extracellular domains: a N-terminal domain and a C-terminal domain. The N-terminal domain consists of a single tyrosine residue, which is the site of the protein's tyrosine kinase activity. The C-terminal domain is a 200-amino acid long tail that is involved in the protein's stability and functions as a scaffold to interact with other proteins.

TRBV12-3 plays a critical role in the immune response by regulating T cell function. T cells are a key mediator of immune responses, and they are responsible for detecting and responding to foreign antigens in the body. TRBV12-3 is involved in this process by regulating the activity of T cells.

One of the functions of TRBV12-3 is to regulate the development and differentiation of T cells. T cells are produced in the bone marrow, and they mature and differentiate into different types of T cells in the body. TRBV12-3 plays a role in regulating the production and function of these T cells by controlling the activity of genes that are involved in T cell development and differentiation.

TRBV12-3 is also involved in regulating the response of T cells to foreign antigens. When a T cell encounters an antigen that it recognizes as foreign, TRBV12-3 is activated and begins to regulate the T cell's response. This includes the activation and proliferation of the T cell, as well as the production of antibodies and other immune molecules.

In addition to its role in T cell development and differentiation, TRBV12-3 is also involved in regulating the immune response more broadly. For example, TRBV12-3 has been shown to be involved in the regulation of inflammation, and it has been suggested as a potential therapeutic target for a variety of inflammatory diseases.

TRBV12-3 is also a potential biomarker for a variety of diseases. For example, high levels of TRBV12-3 have been associated with the development of certain types of cancer, and it has also been shown to be involved in the regulation of aging and age-related diseases. In addition, TRBV12-3 has been suggested as a potential therapeutic target for a variety of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis.

Overall, TRBV12-3 is a protein that is involved in a wide range of important biological processes in the body. Its role in the immune system, T cell development and differentiation, and regulation of inflammation makes it an attractive target for further research and potential therapeutic development. As such, TRBV12-3 is a potential drug target and biomarker for a variety of diseases.

Protein Name: T Cell Receptor Beta Variable 12-3

Functions: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBV12-3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBV12-3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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