GPS1: A Protein Involved in Cell Processes and Disease Development

Target Name: GPS1

NCBI ID: G2873

GPS1

GPS1: A Protein Involved in Cell Processes and Disease Development

GPS1 (COP9 signalosome complex subunit 1) is a protein that is expressed in various tissues and cells in the human body. It is a key component of the COP9 signalosome complex, which is a protein complex that is involved in the regulation of cellular processes such as DNA replication, apoptosis, and autophagy. GPS1 has also been shown to play a role in the development and progression of various diseases, including cancer. As a result, GPS1 has potential as a drug target or biomarker.

GPS1 was first identified in the late 1990s as a component of the COP9 signalosome complex. The COP9 signalosome complex is a protein complex that is composed of several different subunits, including GPS1, which is a subunit that contains the N-terminus of the protein. GPS1 is also known as P100, and it is a 21-kDa protein that is expressed in various tissues and cells in the human body.

GPS1 is involved in the regulation of cellular processes that are important for the survival and growth of cells. One of the functions of GPS1 is to interact with the protein p21, which is a transcription factor that is involved in the regulation of apoptosis. GPS1 has has been shown to play a role in the regulation of apoptosis, by which cells undergo programmed cell death.

In addition to its role in apoptosis, GPS1 is also involved in the regulation of DNA replication and transcription. It has also been shown to interact with the protein narrative (SPT), which is involved in the regulation of DNA replication. to interact with the protein histone acetyltransferase 2 (HAT2), which is involved in the regulation of transcription.

GPS1 has also been shown to be involved in the regulation of autophagy, which is a process by which cells break down and recycle their own damaged or unnecessary components. It has been shown to interact with the proteinBeclin-1 (BECN1), which is involved in the regulation of autophagy.

In addition to its role in the regulation of cellular processes, GPS1 has also been shown to play a role in the development and progression of various diseases. For example, GPS1 has been shown to be involved in the regulation of the transition from cell proliferation to cell differentiation, which is a process that is important for the development of tissues and organs.

GPS1 has also been shown to be involved in the regulation of cell signaling pathways, including the TGF-β pathway. TGF-β is a signaling pathway that is involved in the regulation of cellular processes such as cell growth, differentiation, and inflammation. GPS1 has been shown to interact with the protein Smad4, which is a component of the TGF-β pathway.

In conclusion, GPS1 is a protein that is involved in the regulation of various cellular processes that are important for the survival and growth of cells. It has been shown to play a role in the regulation of apoptosis, DNA replication, transcription, and autophagy. GPS1 has also been shown to be involved in the development and progression of various diseases, including cancer. As a result, GPS1 has potential as a drug target or biomarker.

Protein Name: G Protein Pathway Suppressor 1

Functions: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction

The "GPS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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