Discovering PAQR9: A Key Regulator of Lipid Metabolism (G344838)

Target Name: PAQR9

NCBI ID: G344838

PAQR9

Discovering PAQR9: A Key Regulator of Lipid Metabolism

Progestin and adipoQ receptor family member 9 (PAQR9) is a G protein-coupled receptor that is expressed in various tissues and cells throughout the body. It is a key regulator of lipid metabolism and has been implicated in the development and progression of various diseases, including obesity, type 2 diabetes, and cardiovascular disease. Despite its potential as a drug target, little is known about PAQR9 and its function in human biology.

PAQR9 is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling. The GPCR family includes 伪, 尾, 纬, 未, 蔚, 味, 畏, theta, vi and ix subfamilies. PAQR9 belongs to the eta subfamily, also known as the Progestin and adipoQ receptor family. Members of this family include PAQR1, PAQR2, PAQR3, PAQR4, PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9. PAQR9 is the last member of this family to be discovered.

Positioning of PAQR9

The location of PAQR9 on the human chromosome is Xp21.1. The protein encoded by the PAQR9 gene is a polypeptide chain of 120 amino acids. The promoter of the PAQR9 gene is located on the short arm of the eighth pair of chromosomes, and its gene coding region contains multiple conserved DNA binding sites, which may be necessary for the gene expression and function of PAQR9.

The role of PAQR9

PAQR9 is an important protein that plays various physiological roles in organisms. PAQR9 plays an important role in regulating lipid metabolism. Lipid metabolism is an important process in intracellular energy metabolism and energy storage. PAQR9 controls lipid metabolism by regulating adipocyte growth and fat storage.

PAQR9 is also related to cell signal transduction. PAQR9 can interact with a variety of signaling molecules, including insulin, growth factors, and intracellular chemicals. These interactions enable PAQR9 to play important biological functions within cells.

The relationship between PAQR9 and diseases

PAQR9 is associated with a variety of diseases. Variations in PAQR9 are associated with the development of a variety of diseases, including obesity, diabetes, cardiovascular disease, and neurological disease. Studies have shown that PAQR9 variants are associated with the risk of obesity and diabetes. In addition, PAQR9 variants are associated with the risk of cardiovascular and neurological diseases.

Drug development for PAQR9

PAQR9 has been widely explored in research as a potential drug target. Many studies have shown that agonists of PAQR9 can significantly reduce body weight and fat content in mice or humans. In addition, PAQR9 antagonists are also used to treat obesity and diabetes. These drugs can significantly improve patients' weight and blood sugar levels.

Biological functions of PAQR9

PAQR9 plays a variety of biological functions in organisms. PAQR9 regulates adipocyte growth and fat storage. PAQR9 controls lipids by inhibiting adipocyte growth and fat storage

Protein Name: Progestin And AdipoQ Receptor Family Member 9

Functions: Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870)

The "PAQR9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PAQR9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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