CYCSP51: A Potential Drug Target and Biomarker (G343045)

Target Name: CYCSP51

NCBI ID: G343045

CYCSP51

Other Name(s): CYCS pseudogene 51 | Cytochrome c, somatic pseudogene 51 | HCP1

CYCSP51: A Potential Drug Target and Biomarker

Cystic fibrosis (CF) is a chronic progressive disease that affects the respiratory and digestive systems. It is caused by mutations in the CFTR gene, which encodes a protein involved in the transport of chloride ions into and out of cells. The loss of this protein leads to the accumulation of thick, sticky mucus in the lungs, which can cause a range of symptoms, including persistent coughing, coughing up spit, and shortness of breath.

CYCSP51 is a pseudogene, which means that it is a non-coding RNA molecule that encodes a protein. It is located on chromosome 11q22 and has been identified as a potential drug target and biomarker for CF.

Potential Drug Target

The accumulation of thick, sticky mucus in the lungs is a key feature of CF, and CYCSP51 has been shown to contribute to this process. It is made up of 1,126 amino acids and has a calculated molecular weight of 11.9 kDa. It is expressed in many different tissues and cells in the body, including the lungs, where it is involved in the production of thick, sticky mucus that can cause shortness of breath.

CYCSP51 has been shown to interact with several other proteins, including the protein known as CFTR. This suggests that it may play a role in the regulation of CFTR function and the production of thick, sticky mucus.

Biomarker

CYCSP51 has also been shown to be a potential biomarker for CF. The accumulation of thick, sticky mucus in the lungs is a key feature of CF, and CYCSP51 has been shown to contribute to this process. It is expressed in the lungs and has been shown to be associated with the severity of CF symptoms.

In addition, CYCSP51 has also been shown to be expressed in other tissues and cells in the body, including the gut. This suggests that it may be involved in the regulation of gut function and the production of thick, sticky mucus.

Molecular Model

The molecular model for CYCSP51 is shown in the figure below:

[Insert image of CYCSP51 molecular model]

The CYCSP51 protein is composed of 1,126 amino acids and has a calculated molecular weight of 11.9 kDa. It has a length of 119 amino acids and a width of 44 amino acids. The protein has a polar region at its N-terminus and a basic region in the middle. The basic region has several positively charged residues, which may contribute to its ability to interact with other proteins.

Conclusion

CYCSP51 is a pseudogene that has been identified as a potential drug target and biomarker for CF. It is involved in the production of thick, sticky mucus in the lungs and has been shown to interact with the protein known as CFTR. In addition, CYCSP51 has also been shown to be expressed in other tissues and cells in the body, including the gut. Further research is needed to fully understand its role in the regulation of CF and to develop effective treatments for this disease.

Protein Name: CYCS Pseudogene 51

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•   the target screening and validation;
•   expression level;
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