Understanding The Role of CYP24A1 in Drug Metabolism and Physiological Processes

Target Name: CYP24A1

NCBI ID: G1591

CYP24A1

Understanding The Role of CYP24A1 in Drug Metabolism and Physiological Processes

CYP24A1, a member of the Cytochrome P450 (CYP) family 24 subfamily A, is a gene that has been identified as a potential drug target or biomarker for various diseases. CYP24A1 is a cytochrome P450 enzyme that is expressed in various tissues and cells in the body, including the liver, lung, and pancreas. It is involved in the metabolism of a wide variety of drugs, including many statins, antidepressants, and benzodiazepines.

The CYP24A1 gene has been studied extensively, and many studies have identified variants of the gene that are associated with altered drug metabolism and response. One of the most well-studied variants is the CYP24A1 transcript variant 1, which is a common variants found in many individuals.

In addition to its role in drug metabolism, CYP24A1 is also involved in the regulation of various physiological processes in the body. For example, it is involved in the synthesis of various compounds that are involved in cell signaling, such as adenosine and calcitonin. It is also involved in the regulation of inflammation, as it has been shown to play a role in the production of pro-inflammatory cytokines.

Due to its involvement in a wide range of physiological processes, CYP24A1 has been identified as a potential drug target or biomarker for a variety of diseases. For example, several studies have suggested that individuals with certain genetic variants of CYP24A1 may be at increased risk for developing cardiovascular disease, and that these individuals may benefit from treatment with statins.

In addition, CYP24A1 has also been identified as a potential biomarker for several other diseases, including cancer and neurodegenerative disorders. For example, studies have shown that individuals with certain genetic variants of CYP24A1 may be at increased risk for developing pancreatic cancer, and that these individuals may benefit from screening and treatment.

Overall, CYP24A1 is a gene that has significant implications for our understanding of drug metabolism and the regulation of various physiological processes in the body. Further research is needed to fully understand the role of CYP24A1 in these processes, as well as its potential as a drug target or biomarker for various diseases.

Protein Name: Cytochrome P450 Family 24 Subfamily A Member 1

Functions: A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:24893882, PubMed:15574355, PubMed:8679605, PubMed:11012668, PubMed:16617161, PubMed:29461981). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid (PubMed:24893882, PubMed:15574355). With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product (PubMed:11012668, PubMed:8679605). Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol (PubMed:25727742). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin (PubMed:8679605)

The "CYP24A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYP24A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets