CYB561A3: A Potential Drug Target for Neural Signaling and Inflammation

Target Name: CYB561A3

NCBI ID: G220002

CYB561A3

CYB561A3: A Potential Drug Target for Neural Signaling and Inflammation

CYB561A3, also known as MGC20446, is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and pancreas. It is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a critical role in cellular signaling.

One of the unique features of CYB561A3 is its expression pattern. It is highly expressed in the brain and pancreas, and its levels are lower in other tissues such as the heart and liver. This is important because it suggests that CYB561A3 may be involved in neural signaling, which is a critical function for many organisms, including humans.

In addition to its expression pattern, CYB561A3 has also been shown to play a role in cellular signaling. It is a potent positive modulator of the protein kinase Bcr/Abl, which is involved in cell proliferation and survival. This means that when CYB561A3 is activated, it can increase the activity of Bcr/Abl, which in turn can lead to the growth and survival of cells.

Another potential function of CYB561A3 is its role in inflammation. It has been shown to be involved in the regulation of inflammation in various tissues, including the pancreas and the liver. This is important because many diseases, such as diabetes and liver disease, are characterized by chronic inflammation.

CYB561A3 is also of interest because it is a potential drug target. Its unique expression pattern and its involvement in cellular signaling and inflammation make it a promising target for small molecules. Currently, there are several drug candidates that are being developed to specifically target CYB561A3, with the goal of using these drugs to treat a variety of diseases.

In conclusion, CYB561A3 is a protein that is expressed in various tissues of the body and is involved in cellular signaling and inflammation. Its unique expression pattern and its involvement in critical functions make it a promising target for small molecules. Further research is needed to fully understand the role of CYB561A3 in neural signaling and to identify potential drug targets.

Protein Name: Cytochrome B561 Family Member A3

Functions: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis

The "CYB561A3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYB561A3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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