CYP1A1: A Key Player in The Body's Metabolism (G1543)

Target Name: CYP1A1

NCBI ID: G1543

CYP1A1

CYP1A1: A Key Player in The Body's Metabolism

CYP1A1, also known as cytochrome P450-C, is a gene that encodes for a protein known as CYP1A1. This gene is a key player in the synthesis of many compounds, including drugs, toxins, and other harmful substances. It is a member of the cytochrome P450 enzyme superfamily, which is responsible for metabolizing a wide variety of molecules.

One of the primary functions of CYP1A1 is to metabolize drugs that are used to treat various diseases, such as heart disease, diabetes, and cancer. It is also involved in the metabolism of many other substances, including toxins and other harmful substances that are found in the environment.

CYP1A1 is expressed in most tissues and cells in the body, and it is highly regulated by the body's natural processes. It is expressed in the liver, as well as in other organs such as the lungs, kidneys, and intestines. It is also expressed in the placenta, which plays a critical role in the transfer of drugs from the mother to the child.

CYP1A1 has been identified as a potential drug target for several reasons. Firstly, it is involved in the metabolism of many drugs that are used to treat various diseases. For example, CYP1A1 is involved in the metabolism of statins, which are used to treat heart disease. It is also involved in the metabolism of other drugs that are used to treat cancer, such as chemotherapy drugs.

Secondly, CYP1A1 is a good candidate for a biomarker, which is a substance that is used to diagnose or monitor a specific disease or condition. The metabolism of drugs by CYP1A1 can be monitored to determine the effectiveness of a drug or to identify potential side effects. This information can be used to improve the safety and effectiveness of drugs, as well as to develop new drugs that are more effective and less harmful.

Thirdly, CYP1A1 is involved in the synthesis of many other compounds, including toxins and other harmful substances. This means that it is involved in the production of many natural compounds that are essential to life. However, some of these compounds can also be harmful and can cause diseases when consumed in excess. The metabolism of these compounds by CYP1A1 can help to identify potential toxins and to determine the safe use of drugs.

Overall, CYP1A1 is a gene that is involved in many important processes in the body. It is a potential drug target, a biomarker, and an essential compound in the synthesis of natural compounds. Further research is needed to fully understand the role of CYP1A1 in the body and to develop new treatments based on this protein.

Protein Name: Cytochrome P450 Family 1 Subfamily A Member 1

Functions: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195)

The "CYP1A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYP1A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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